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See Latest ArticlesIntranasal midazolam: a comparison of two delivery devices in human volunteers
Journal of Pharmacy and Pharmacology, 11/16/06
Dale, Ola, et al. - Conclusion: Adverse effects such as local irritation did not differ significantly between the sprays. Apparently bidirectional delivery did not increase systemic bioavailability of midazolam. We cannot disregard that only the traditional spray caused less sedation than intravenous administration. This finding needs to be confirmed in trials designed for this purpose
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