Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence

Neuropsychopharmacology, 05/18/2012

These results demonstrate that the escalation of nicotine intake only occurs in animals given intermittent periods of abstinence with extended access to nicotine, and that inhibition of monoamine oxidase may contribute to the escalation of smoking, thus validating both an experimantal model of the escalation of smoking behavior and the contribution of monoamine oxidase inhibition to compulsive nicotine–seeking.

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