Associations between abcc2 polymorphisms and cisplatin disposition and efficacy

Clinical Pharmacology & Therapeutics, 05/14/2012

These SNPs were also not correlated with ABCC2 expression in the NCI60 panel (P > 0.26) or with cisplatin–induced cytotoxicity (P = 0.21). These findings highlight the importance of verifying drug–transporter interactions with in vitro tests in humans.

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