Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

PLoS Neglected Tropical Diseases, 05/08/2012

Here, author present a new way of determining the mode of action of a drug by measuring how the levels of small molecules comprising the cellular metabolome are perturbed when exposed to drugs. They show that eflornithine causes the changes in polyamine metabolism previously known to underlie its mode of action.

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