The ssri citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of sert antagonism
Neuropsychopharmacology, 03/30/2012Bonnin A et al.
These results reveal a novel σ1 activity in modulating axon guidance and a 5–HT independent action of a widely prescribed SSRI. By extension, (RS)–CIT and possibly other structurally similar SSRIs may have other off–target actions that can impact neural development and contribute to therapeutic efficacy or side effects.
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