Weekly vs. daily administration of oral methotrexate (MTX) for generalized plaque psoriasis: a randomized controlled clinical trial

International Journal of Dermatology, 10/10/2011

Nausea, vomiting, headache, and fatigue were significantly less common side effects in the patients who received MTX daily, but liver enzyme abnormalities were less common, and clinical efficacy was greater in the patients who received MTX weekly.

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