Clinical Challenges in Addressing Resistance to Antimicrobial Drugs in the Twenty-First Century Septimus EJ et al. - Among the gram-positive pathogens, methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus species are the biggest threats. The situation is even more alarming with respect to gram-negative pathogens, especially because there are currently no late clinical trials involving new anti-infective drugs that are active against these pathogens. [more...]