Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3 Musch MW et al. - Activation of intestinal epithelial a2AR significantly blocks the inhibition of apical Na+ transporters by cAMP- and Ca++-mediated pathways and also directly increases apical sodium/hydrogen exchange activities. By both blocking electrolyte secretion and promoting absorption, alpha2-agonists could be potent anti-diarrheal agents that could directly counteract the actions of toxigenic pathogens and other secretatogues causing secretory diarrhea. [more...]
