Factorial designed experiment to study the effects of excipients on the mechanical properties of pellets
Bashaiwoldu, Abraham B., et al. - The aim of this work was to determine the effects of formulation factors on the mechanical properties of pellets produced by the process of extrusion and spheronisation. It was found that the spheronisation aid used, microcrystalline cellulose, is the domineering factor in most mechanical properties studied, except for the surface tensile strength, which decreased significantly with an increase in glyceryl monostearate concentration. The change in binder liquid from water to a water/ethanol mixture further changed the behaviour of the systems significantly [more...]
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