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Evans MS et al. – These results build on previous work indicating that TRPV1 channels in trigeminal nociceptors play a role in craniofacial pain. These findings that TRPV1 is inhibited by the specific antimigraine drug sumatriptan, and that TRPV1 channels are functional in neurons projecting to cerebral dura suggests a specific role for these channels in migraine or cluster headache.Methods
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