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Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
Current Medical Research and Opinion, 07/01/09
Graefe-Mody EU et al. - In this small, multiple dose study carried out in healthy subjects, co-administration of linagliptin with metformin did not have a clinically relevant effect on the pharmacokinetics or pharmacodynamics of either agent. This study suggests linagliptin and metformin can safely be administered concomitantly in type 2 diabetes patients without dose adjustment; larger, longer-term clinical trials in diabetic patients are underway.
Today in Dosing...keeping you current
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High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial
BMC Infectious Diseases, 12/03/09
Ustekinumab (Stelara): First-in-class human monoclonal antibody approved for treatment of moderate-to-severe plaque psoriasis
Formulary , 12/02/09
A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate
Expert Opinion in Pharmacotherapy, 12/01/09
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Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children
Malaria Journal, 12/01/09
Pharmacokinetic—pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide
Clinical Therapeutics, 12/01/09
Drug-Drug Interaction Between Itraconazole and the Protease Inhibitor Lopinavir/Ritonavir
Annals of Pharmacotherapy, 11/25/09
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Sex-Based Differences in Drug Activity
American Family Physician, 12/02/09
Pharmacokinetics and safety of fibrinogen concentrate
Journal of Thrombosis and Haemostasis, 12/02/09
Impaired Renal Function and Opioid Toxicity
Journal Of Pain & Palliative Care Pharmacotherapy, 12/02/09

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