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Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
Current Medical Research and Opinion, 07/01/09
Graefe-Mody EU et al. - In this small, multiple dose study carried out in healthy subjects, co-administration of linagliptin with metformin did not have a clinically relevant effect on the pharmacokinetics or pharmacodynamics of either agent. This study suggests linagliptin and metformin can safely be administered concomitantly in type 2 diabetes patients without dose adjustment; larger, longer-term clinical trials in diabetic patients are underway.
Today in Dosing...keeping you current
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Drug dosage protocol for calcium oxalate stone
Urological Research - Urolithiasis, 10/23/09
Risperidone dose for schizophrenia
Cochrane Reviews, 10/21/09
Pediatric antifungal agents
Current Opinion in Infectious Diseases, 10/28/09
Today in Drug Interactions...keeping you current
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An evidence-based assessment of the clinical significance of drug-drug interactions between disease-modifying antirheumatic drugs and non-antirheumatic drugs according to rheumatologists and pharmacists
Clinical Therapeutics, 10/15/09
Meta-analysis of doripenem vs comparators in patients with pseudomonas infections enrolled in four phase III efficacy and safety clinical trials
Current Medical Research and Opinion, 10/27/09
Quality of Life Improvements Attributed to Combination Therapy with Oral and Topical Mesalazine in Mild-to-Moderately Active Ulcerative Colitis
Digestion, 10/15/09
Today in Pharmacokinetics...keeping you current
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Pediatric antifungal agents
Current Opinion in Infectious Diseases, 10/28/09
Pharmacokinetics and Antihypertensive Effects of Candesartan Cilexetil in Patients Undergoing Haemodialysis: An Open-Label, Single-Centre Study
Clinical Drug Investigation, 10/15/09
Antiviral Agents for Influenza: Molecular Targets, Concerns of Resistance, and New Treatment Options
Current Drug Targets, 10/23/09
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