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See Latest ArticlesUpregulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17 beta-Estradiol: a Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy
Drug Metabolism and Disposition, 06/23/09
Chen H et al. - Data indicate that upregulation of UGT1A4 expression by E2 is mediated by both ER alpha and Sp1, and is a potential mechanism contributing to the enhanced elimination of lamotrigine in pregnancy.
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