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See Latest ArticlesCardiomyocyte S1P1 Receptor-mediated Extracellular Signal-related Kinase Signaling and Desensitization
Journal of Cardiovascular Pharmacology, 06/26/09
Tao R et al. - Cell death induced by hypoxia/reoxygenation was reduced by pretreatment with exogenous S1P. This enhanced survival was abrogated by pretreatment with PD98059, VPC23019, or pertussis toxin. Thus, exogenous S1P induces rapid and reversible S1P1-mediated ERK phosphorylation.
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