Your Article Summary
See Latest ArticlesPharmacokinetics of duloxetine hydrochloride enteric-coated tablets in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study
Clinical Therapeutics, 06/23/09
Zhao RK et al. - In these healthy Chinese subjects, AUC and Cmax increased proportionally with the dose, whereas t1/2 was independent of the dose. Linear PK properties were found at doses of 30 to 90 mg. No statistically significant differences were observed between the PK parameters for the subjects in the multiple-dose phase (t1/2, CL, Vd) and those for subjects in the single-dose phase. The AUC and Cmax were greater after administration of multiple doses than after administration of a single dose, suggesting du-loxetine accumulation with multiple-dose administration of 30 mg.
Related Articles
Evaluation of Cynomolgus Monkey PXR, Primary Hepatocyte and In Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction
Drug Metabolism and Disposition, 10/21/09
Relevance Score: 89%
Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein inhibitor, in healthy subjects
British Journal of Clinical Pharmacology, 10/20/09
Relevance Score: 89%
Antiretroviral Adherence and Pharmacokinetics: Review of their Roles in Sustained Virologic Suppression
AIDS Patient Care and STDs, 10/05/09
Relevance Score: 89%
Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in children
Acta Anaesthesiologica Scandinavica, 10/16/09
Relevance Score: 88%
Pharmacokinetic Outcomes of a Simplified, Weight-Based, Extended-Interval Gentamicin Dosing Protocol in Critically Ill Neonates
Pharmacotherapy, 10/27/09
Relevance Score: 87%
Today in Pharmacokinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Safety of Oseltamivir Compared With the Adamantanes in Children Less Than 12 Months of Age
The Pediatric Infectious Disease Journal, 12/15/09
Evaluating pharmacokinetics and pharmacodynamics of intravenous busulfan in pediatric patients receiving bone marrow transplantation
Pediatric Transplantation, 12/15/09
'Party pill' drugs - BZP and TFMPP
New Zealand Medical Journal, 12/14/09