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Pharmacokinetics of duloxetine hydrochloride enteric-coated tablets in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study
Clinical Therapeutics, 06/23/09

Zhao RK et al. - In these healthy Chinese subjects, AUC and Cmax increased proportionally with the dose, whereas t1/2 was independent of the dose. Linear PK properties were found at doses of 30 to 90 mg. No statistically significant differences were observed between the PK parameters for the subjects in the multiple-dose phase (t1/2, CL, Vd) and those for subjects in the single-dose phase. The AUC and Cmax were greater after administration of multiple doses than after administration of a single dose, suggesting du-loxetine accumulation with multiple-dose administration of 30 mg.

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