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See Latest ArticlesNarrative Review: Statin-Related Myopathy
Annals of Internal Medicine, 06/16/09
Joy TR et al. - Statin-related myopathy comprises myalgias, myositis, and rhabdomyolysis. Myalgias can affect up to 10% of persons prescribed statins, whereas rhabdomyolysis is rare. The mechanisms responsible for statin-related myopathy are unclear but may include decreased levels of coenzyme Q10, decreased bioavailability of isoprenoids, or mitochondrial dysfunction. Risk factors for myopathy include history of myopathy while receiving another lipid-lowering agent, family history of statin-related myopathy, high-dose statin therapy, increased age, female sex, and use of medications metabolized through cytochrome P450 3A4. Assessment of statin-related myopathy includes a search for other causes of creatine kinase elevation and myopathy. Management of statin-related myopathy can include switching agents or use of fluvastatin, low-dose rosuvastatin, nondaily dosing, and ezetimibe or bile acid–binding resins.
Today in Adverse Drug Reactions...keeping you current
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Drugs for preventing malaria in travellers
Cochrane Reviews, 10/22/09
A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding
Clinical Therapeutics, 11/02/09
Incidence and causes of heparin-induced skin lesions
Canadian Medical Association Journal, 10/19/09
Today in Cardiac/Hypertension...keeping you current
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Novartis receives FDA approval for Valturna®, a single-pill combination of valsartan and aliskiren, to treat high blood pressure
Novartis, 09/18/09
Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia
Annals of Internal Medicine, 11/03/09
Nebivolol in High-Risk, Obese African Americans With Stage 1 Hypertension: Effects on Blood Pressure, Vascular Compliance, and Endothelial Function
The Journal of Clinical Hypertension, 10/09/09
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