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Kraychete DC et al. - In patients with herniated intervertebral disks and carpal tunnel syndrome, plasma levels of TNF-alpha and IL-6 were higher than in healthy volunteers, while differences in the concentrations of sTNF-R and IL-1beta were not observed. Plasma levels of TNF-alpha, but not of IL-6, sTNF-R, and IL-1beta, decreased after treatment with tramadol (100 mg every 12 hours).

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