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Shire plc, the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE CII with the proton pump inhibitor Prilosec OTC 40 mg (20 mg X 2), did not alter the median time it took for maximum plasma concentration of d-amphetamine to be reached in the subjects evaluated. In the same study, coadministration of Prilosec OTC with ADDERALL XR resulted in a nearly 45 percent reduction in the median time to reach maximum plasma concentrations of amphetamine, the active medication. Other pharmacokinetic parameters of active medication were not altered for either VYVANSE or ADDERALL XR when coadministered with Prilosec OTC.
Today in Drug Interactions...keeping you current
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Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole
Clinical Pharmacokinetics, 12/18/09
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
Pain, 12/16/09
Cyclosporine Versus Tacrolimus in Immunosuppressive Maintenance Regimens in Renal Transplants in Brazil: Survival Analysis from 2000 to 2004
Annals of Pharmacotherapy, 12/16/09
Today in Major Studies...keeping you current
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A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer
Investigational New Drugs, 12/18/09
Evaluation of Treatment Satisfaction in Children with Allergic Disease Treated with an Antihistamine: An International, Non-Interventional, Retrospective Study
Clinical Drug Investigation, 12/11/09
Sanofi Pasteur Global Dengue Vaccine Clinical Program Expanded in Latin America
Sanofi-aventis, 12/10/09
Today in Over The Counter (OTC)...keeping you current
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GlaxoSmithKline and NanoBio announce OTC licensing agreement for cold sore treatment
GlaxoSmithKline, 12/18/09
Use of over-the-counter analgesics and perceived stress among 25-44-year olds
Pharmacoepidemiology and Drug Safety, 12/16/09
Effect of Obesity on Platelet Reactivity and Response to Low-Dose Aspirin
Preventive Cardiology, 12/15/09
Today in Pharmacokinetics...keeping you current
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Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action
Clinical Pharmacokinetics, 12/18/09
Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole
Clinical Pharmacokinetics, 12/18/09
Population pharmacokinetics of posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome
Current Medical Research and Opinion, 12/17/09
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