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Shire plc, the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE CII with the proton pump inhibitor Prilosec OTC 40 mg (20 mg X 2), did not alter the median time it took for maximum plasma concentration of d-amphetamine to be reached in the subjects evaluated. In the same study, coadministration of Prilosec OTC with ADDERALL XR resulted in a nearly 45 percent reduction in the median time to reach maximum plasma concentrations of amphetamine, the active medication. Other pharmacokinetic parameters of active medication were not altered for either VYVANSE or ADDERALL XR when coadministered with Prilosec OTC.
Today in Drug Interactions...keeping you current
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An evidence-based assessment of the clinical significance of drug-drug interactions between disease-modifying antirheumatic drugs and non-antirheumatic drugs according to rheumatologists and pharmacists
Clinical Therapeutics, 10/15/09
Meta-analysis of doripenem vs comparators in patients with pseudomonas infections enrolled in four phase III efficacy and safety clinical trials
Current Medical Research and Opinion, 10/27/09
Quality of Life Improvements Attributed to Combination Therapy with Oral and Topical Mesalazine in Mild-to-Moderately Active Ulcerative Colitis
Digestion, 10/15/09
Today in Major Studies...keeping you current
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The INFUSE Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients with Advanced Illness
Journal of Pain and Symptom Management, 10/13/09
Psychopharmacology Curriculum Field Test
Academic Psychiatry, 10/16/09
The influence of porosity changes in human epidermal membrane during iontophoresis on the permeability enhancement of a model peptide
Drug Development and Industrial Pharmacy, 10/14/09
Today in Over The Counter (OTC)...keeping you current
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A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding
Clinical Therapeutics, 11/02/09
Aspirin use associated with lower colorectal cancer mortality
American Pharmacists Association, 10/14/09
The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials
Colorectal Disease, 10/15/09
Today in Pharmacokinetics...keeping you current
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Pediatric antifungal agents
Current Opinion in Infectious Diseases, 10/28/09
Pharmacokinetics and Antihypertensive Effects of Candesartan Cilexetil in Patients Undergoing Haemodialysis: An Open-Label, Single-Centre Study
Clinical Drug Investigation, 10/15/09
Antiviral Agents for Influenza: Molecular Targets, Concerns of Resistance, and New Treatment Options
Current Drug Targets, 10/23/09
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