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See Latest ArticlesPrevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulcer: Looking to the Future
Gastroenterology Clinics of North America, 05/21/09
Fiorucci S - Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for treatment of pain and inflammation, despite their association with gastrointestinal complications, including bleeding and perforation. Inhibition of cyclooxygenases (COXs), is the main mechanism of action of aspirin and NSAIDs. Inhibition of COX-1 derived prostanoids in the stomach represent the underlying mechanism involved in development of gastric and duodenal ulcers in patients taking NSAIDs. Selective COX-2 inhibitors (coxibs) spare the gastrointestinal tract, but their use increases the risk of heart attack and stroke.
Today in Adverse Drug Reactions...keeping you current
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Today in Over The Counter (OTC)...keeping you current
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A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding
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Aspirin use associated with lower colorectal cancer mortality
American Pharmacists Association, 10/14/09
Today in Stomach/GI...keeping you current
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Salix Receives FDA Marketing Approval for Metozolv
Salix Pharmaceuticals, 09/10/09
Methotrexate for maintenance of remission in Crohn's disease
Cochrane Reviews, 10/27/09
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