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De Broe ME et al. - Chronic analgesic nephropathy results from daily use for many years of mixtures containing at least two analgesics and caffeine or dependence-inducing drugs. The continued use of non–phenacetin-combined analgesics with or without nonsteroidal anti-inflammatory drugs is associated with faster progression toward renal impairment. As long as high-risk analgesic mixtures are available over the counter, analgesic nephropathy will continue to be a problem.

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