Modafinil for attentional and psychomotor dysfunction in advanced cancer: a double-blind, randomised, cross-over trial
Palliative Medicine, 08/06/2009
Lundorff LE et al. – In a study to investigate the use of modafinil on attentional and psychomotor dysfunction in cancer pts, it was shown that modafinil in a single dose ... regarding 2 cognitive tests of psychomotor speed and attention. Subjective scores of depression and drowsiness were significantly improved by modafinil. Methods- 28 cancer pts with a tiredness score of 50 mm or more on a scale of 0 to 10 (0 = no tiredness, 10 = worst possible ... acting opioids for breakthrough pain.
- On day 1, pts were randomly assigned to receive 200 mg modafinil orally or placebo and on day 4 they crossed–over to the alternative treatment.
- Finger Tapping Test (FTT), Trail Making Test (TMT) and Edmonton Symptom Assessment System (ESAS ... significantly improved on modafinil.
- On ESAS, depression and drowsiness also improved statistically significantly
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Armodafinil and Modafinil Have Substantially Different Pharmacokinetic Profiles Despite Having the Same Terminal Half-Lives: Analysis of Data from Three Randomized, Single-Dose, Pharmacokinetic Studies
Clinical Drug Investigation, 08/13/2009
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Darwish M et al. – Despite similar half–lives, plasma concentrations following ... late in the day than those following modafinil administration on a milligram–to–milligram basis. The different pharmacokinetic profile of armodafinil may result in improved wakefulness throughout the day in patients with ES compared with modafinil.
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Effect of Modafinil on Subjective Fatigue in Multiple Sclerosis and Stroke Patients
European Neurology, 08/25/2009
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Brioschi A et al. – Modafinil was tolerated in 75% of patients at small doses and seemed to improve the severity of fatigue in the MS and BDS groups but not in the CS group. There was no modification in ... physical activity.
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Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills
Acta Anaesthesiologica Scandinavica, 09/04/2009
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Galvin E et al. – Early recovery of patients following sedation/analgesia and anesthesia is important in ambulatory practice. Modafinil reduces patient–reported ... tiredness after sedation/analgesia but does not improve recovery in terms of objective measures of patient psychomotor skills.
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Modafinil improves information processing speed and increases energetic resources for orientation of attention in narcoleptics: Double-blind, placebo-controlled ERP studies with low-resolution brain electromagnetic tomography (LORETA)
Sleep Medicine, 08/27/2009
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Saletu M et al. – LORETA revealed that modafinil improved
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Comparison of Steady-State Plasma Concentrations of Armodafinil and Modafinil Late in the Day Following Morning Administration: Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Studies in Healthy Male Subjects
Clinical Drug Investigation, 08/13/2009
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Darwish M et al. – At steady state ... the day than modafinil when compared on a milligram–to–milligram basis. The distinct pharmacokinetic profile of armodafinil compared with that of the racemate may result in fundamentally different durations of action. These differences between the two medications cannot be made
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Agent battles excessive sleepiness
The Clinical Advisor, 09/01/2009
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Adjunct to standard treatment for underlying airway obstruction in OSAHS. Armodafinil is the R–enantiomer of modafinil (Provigil). Of the two enantiomers that comprise modafinil, the R–form is longer lasting. Both of these drugs have wakefulness– promoting effects similar to those
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Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology
Journal of Medical Ethics, 10/26/2009
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Cakic V – Reports in the popular press suggest that smart drugs or "nootropics" such as methylphenidate, modafinil and piracetam are increasingly being used by the healthy to augment cognitive ability. Although current nootropics offer only modest improvements
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Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work Disorder
Cephalon, 11/03/2009
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throughout the shift in patients with excessive sleepiness associated with shift work disorder. NUVIGIL, the longer–lasting isomer of modafinil, is indicated to improve wakefulness in patients with excessive sleepiness associated with shift work disorder, treated obstructive sleep apnea and
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Cancer-Related Fatigue: The Approach and Treatment
Journal of General Internal Medicine, 10/21/2009
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such as psychosocial interventions, exercise, sleep therapy, and acupuncture. Pharmacologic interventions include stimulants, namely modafinil and methylphenidate. In some patients antidepressants may be beneficial. Clinicians should assess cancer survivors for the presence of fatigue and focus on
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