Modafinil for multiple sclerosis fatigue: Does it work
Clinical Neurology and Neurosurgery, 12/18/2009
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Littleton ET et al. – This suggests that modafinil may be useful, particularly when MS fatigue is associated with sleepiness. The relationship between fatigue and excessive daytime sleepiness is poorly understood and needs to be better ... measures of the most clinically relevant outcomes can be selected for clinical trials. Outcome measures used in previous clinical trials have not properly evaluated the effects of modafinil.
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Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills
Acta Anaesthesiologica Scandinavica, 09/04/2009
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Galvin E et al. – Early recovery of patients following sedation/analgesia and anesthesia is important in ambulatory practice. Modafinil reduces patient–reported ... tiredness after sedation/analgesia but does not improve recovery in terms of objective measures of patient psychomotor skills.
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Agent battles excessive sleepiness
The Clinical Advisor, 09/01/2009
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Adjunct to standard treatment for underlying airway obstruction in OSAHS. Armodafinil is the R–enantiomer of modafinil (Provigil). Of the two enantiomers that comprise modafinil, the R–form is longer lasting. Both of these drugs have wakefulness– promoting effects similar to those
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Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology
Journal of Medical Ethics, 10/26/2009
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Cakic V – Reports in the popular press suggest that smart drugs or "nootropics" such as methylphenidate, modafinil and piracetam are increasingly being used by the healthy to augment cognitive ability. Although current nootropics offer only modest improvements
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Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work Disorder
Cephalon, 11/03/2009
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throughout the shift in patients with excessive sleepiness associated with shift work disorder. NUVIGIL, the longer–lasting isomer of modafinil, is indicated to improve wakefulness in patients with excessive sleepiness associated with shift work disorder, treated obstructive sleep apnea and
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Cancer-Related Fatigue: The Approach and Treatment
Journal of General Internal Medicine, 10/21/2009
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such as psychosocial interventions, exercise, sleep therapy, and acupuncture. Pharmacologic interventions include stimulants, namely modafinil and methylphenidate. In some patients antidepressants may be beneficial. Clinicians should assess cancer survivors for the presence of fatigue and focus on
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