Top inhaled steroids Articles in Pharmacy

Predictive value and utility of oral steroid testing for treatment of COPD in primary care: the COOPT study
International Journal of COPD, 11/19/2009

Chavannes NH et al. – Oral steroid testing identifies a limited proportion of COPD patients, but does not reveal any clinically relevant benefit from inhaled steroid treatment on health status ... exacerbation rate and lung function decline occurred. [more...]

Increased vagal airway tone in fatal asthma
Medical Hypotheses, 11/30/2009

ndash;fatal events. If the airway tone is increased, individuals should be treated with a triple combination of long–acting beta2 agonists, inhaled steroids, and inhaled anticholinergics to prevent vagally mediated fatal events. [more...]

Evaluation of laryngeal findings in users of inhaled steroids
European Archives of Oto-Rhino-Laryngology, 11/17/2009

Acar GO et al. – The authors consider that steroid myopathy or mucosal inflammatory theory alone is not sufficient to explain the etiopathogenesis of dysphonia in asthmatic patients taking ICS. The laryngeal mucosal changes were [more...]

Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma
European Respiratory Journal, 12/15/2009

De Llano lap et al. – The current results suggest that FeNO can identify patients with difficult–to–treat asthma and the potential to respond to high doses of inhaled corticosteroids or systemic steroids. [more...]

Low levels of steroid-metabolizing hepatic enzyme activity may elevate responsiveness to steroids and may increase risk of steroid-induced osteonecrosis even with low glucocorticoid dose
Journal of Orthopaedic Science, 12/18/2009

Tokuhara Y et al. – The findings suggest that low CYP3A activity may be vulnerable to the effect of steroids and ... increase risk of osteonecrosis, even with a low dose of steroid. [more...]

Pharmacology of steroids used during epidural steroid injections
Techniques in Regional Anesthesia and Pain Management, 11/20/2009

Kushnerik V et al. – The most commonly used steroid preparations for the neuraxial blockade are methylprednisolone acetate (Depo–Medrol, Pfizer, New York, NY), triamcinolone acetonide and diacetate (Kenalog, Bristol&ndash ... protein metabolism. The formulations available for injectable steroids contain various chemicals, which include buffers, polyethylene glycol, benzyl alcohol, and benzalkonium chloride. Toxicities that are associated with epidural steroid injections (ESIs) are often delayed. There have been several ... following transforaminal ESIs. The most accepted explanation for this is an occlusion of the segmental artery by the steroid particulate matter or embolization through the vertebral artery. [more...]

Ultrasound guidance for epidural steroid injections
Techniques in Regional Anesthesia and Pain Management, 11/20/2009

Shankar H et al. – Ultrasound (US) guidance is practiced widely in regional anesthesia. It is becoming increasingly used for pain medicine interventions. US–guided neuraxial analgesia has also been demonstrated despite many technical ... US guidance for neuraxial steroid injections adds the dimension of complications secondary to particulate steroids. This review will discuss the available evidence for the use of US in neuraxial analgesia and for epidural steroid injections (ESIs), the technique and limitations, and the potential ... medicine,spine,pain management,interventional,ultrasound,radiology/diagnostics,radiology,anesthesia,neurology,orthopedics,anesthesiology [more...]

The mechanism of action and side effects of epidural steroids
Techniques in Regional Anesthesia and Pain Management, 11/20/2009

Baqai A et al. – This paper assesses the multiple mechanisms of action of epidural steroids in the treatment of back pain on the mechanical, cellular, and molecular levels and reviews the systemic side effects of epidural steroid usage. A review of ... aided search of recently published articles within the last 10 years to find the most recent information on the mechanism of action of epidural steroids. The studies discussed in this paper focus on the theories underlying the various anti–inflammatory actions of glucocorticoids, as well as ... management,orthopedic/physical med,anesthesia,orthopedics,anesthesiology,pharmacy,family medicine,internal medicine [more...]

Epidural steroid injections: An update on mechanisms of injury and safety
Techniques in Regional Anesthesia and Pain Management, 11/23/2009

Gharibo C et al. – With the ever–increasing use of epidural steroids, there has been a disproportionate increase in popularity of transforaminal ESIs in particular. Since 2002, there has been a growing body of ... transforaminal epidural steroid case report literature that describes paralysis, stroke, and death that immediately follows the performance of these procedures. These complications are thought to be related to a combination of factors, which may include the technique used, underlying pathophysiology ... as well as the specific injectate used. This article discusses the pathogenesis of these complications and puts the role of steroids in their causation into perspective. [more...]

Sirolimus for treatment of steroid-refractory acute graft-versus-host disease
Bone Marrow Transplantation, 12/11/2009

Hoda D et al. – CR was achieved in 11 (42%) of 31 steroid–refractory and 2 (67%) of 3 steroid–intolerant patients. Median OS after initiation of sirolimus was 5.6 months, and 1–year OS was 44% (95 ... effective in controlling steroid–refractory aGVHD. [more...]