Drug absorption interactions between oral targeted anticancer agents and ppis: is ph-dependent solubility the achilles heel of targeted therapy?
Clinical Pharmacology & Therapeutics, 07/16/2012
Budha NR et al. – The currently available clinical data suggest that the magnitude of this DDI is largest for compounds whose in vitro solubility varies over the pH range 1–4. This range represents the normal physiological gastric acidity (pH –1) and gastric acidity while on an acid–reducing agent (pH –4).