Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy

The Journal of Clinical Pharmacology, 05/08/2012

There was no pregnancy–induced effect in the apparent clearances (CL) of either doxylamine or pyridoxal 5'–phosphate (PLP) in women during the first trimester of pregnancy despite the existence of morning sickness.

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