Adjuvants are becoming more common in vaccine and other drug formulations to increase therapeutic response. Some of these substances, however, are close enough in size to bacteria that they are unable to pass through sterilizing–grade filters. Others have low surface tension that can reduce a filter's bacterial retention. As a result, adjuvants can cause premature plugging of filter membranes and reduce filter capacity. BioPharm International spoke to several industry experts to gain insight on resolving these technical challenges.
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