Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology to pediatric surgery, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.
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1 The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents Pediatric Obesity, May 13, 2013 Review Article Clinical Article
2 Prevention of steroid-induced low bone mineral density in children with renal diseases: a systematic review Nephrology Dialysis Transplantation, May 13, 2013 Evidence Based Medicine Review Article Clinical Article
3 High Prevalence of Autoimmune Thyroiditis in Children and Adolescents with Vitiligo Hormone Research in Paediatrics, May 13, 2013 Review Article
4 Risk of Childhood Obesity in the Toddler Offspring of Mothers With Gestational Diabetes Obstetrics and Gynecology, May 13, 2013 Clinical Article
5 Quality of Life and Other Outcomes in Children Treated for Cushing Syndrome Journal of Clinical Endocrinology and Metabolism, May 13, 2013 Review Article Clinical Article
6 Factors Associated With Microalbuminuria in 7,549 Children and Adolescents With Type 1 Diabetes in the T1D Exchange Clinic Registry Diabetes Care, May 13, 2013 Review Article
7 Effects of Recombinant Human Growth Hormone for 1 Year on Body Composition and Muscle Strength in Children on Long-Term Steroid Therapy: Randomized Controlled, Delayed-Start Study Journal of Clinical Endocrinology and Metabolism, May 13, 2013 Clinical Article
8 Role of the Waist/Height Ratio in the Cardiometabolic Risk Assessment of Children Classified by Body Mass Index JACC - Journal of the American College of Cardiology, May 13, 2013 Clinical Article
9 Screening for Congenital Hypothyroidism: Comparison of Borderline Screening Cut-Off Points and the Effect on the Number of Children Treated with Levothyroxine European Thyroid Journal, May 13, 2013 Review Article
10 Thyroid cancer in children and adolescents Current Opinion in Otolaryngology and Head & Neck Surgery, May 13, 2013 Review Article
11 Association between Younger Age When First Overweight and Increased Risk for CKD Journal of the American Society of Nephrology, May 13, 2013 Clinical Article
12 Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: variations by race/ethnicity Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 13, 2013 Review Article
13 Characterizing Short Stature by Insulin-like Growth Factor Axis Status and Genetic Associations: Results From the Prospective, Cross-sectional, Epidemiogenetic EPIGROW Study Journal of Clinical Endocrinology and Metabolism, May 13, 2013 Clinical Article
14 Etanercept Improves Lipid Profile and Oxidative Stress Measures in Patients with Juvenile Idiopathic Arthritis The Journal of Rheumatology, May 13, 2013 Clinical Article
15 Different Long-Term Response to Growth Hormone Therapy in Small- versus Appropriate-for-Gestational-Age Children with Growth Hormone Deficiency Hormone Research in Paediatrics, May 13, 2013 Review Article
16 Endothelial function in children and adolescents with mucopolysaccharidosis Journal of Inherited Metabolic Disease, May 13, 2013
17 The Relationship Between Vitamin D Status and Adrenal Insufficiency in Critically Ill Children Journal of Clinical Endocrinology and Metabolism, April 18, 2013 Review Article
18 Differences in the management of adolescents with polycystic ovary syndrome across pediatric specialties Journal of Pediatric and Adolescent Gynecology , April 18, 2013 Clinical Article
19 Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis International Journal of Obesity, April 18, 2013 Review Article
20 Fructose intake and cardiovascular risk factors in youth with type 1 diabetes: SEARCH for diabetes in youth study Diabetes Research and Clinical Practice, April 18, 2013 Clinical Article
21 Effects of Promoting Longer-term and Exclusive Breastfeeding on Adiposity and Insulin-like Growth Factor-I at Age 11.5 Years: A Randomized Trial JAMA, April 18, 2013 Clinical Article
22 Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome Journal of Clinical Endocrinology and Metabolism, April 18, 2013 Evidence Based Medicine Clinical Guideline
23 Switching to Sulphonylureas in Children With iDEND Syndrome Caused by KCNJ11 Mutations Results in Improved Cerebellar Perfusion Diabetes Care, April 18, 2013 Review Article
24 Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels Diabetologia - Clinical and Experimental Diabetes and Metabolism, April 18, 2013 Review Article
25 Subclinical hypothyroidism in the first years of life in patients with Down syndrome Pediatric Research, March 24, 2013 Review Article
26 Genetic associations with neonatal thyroid-stimulating hormone levels Pediatric Research, March 24, 2013 Review Article
27 Congenital Hypothyroidism due to Defects of Thyroid Development and Mild Increase of TSH at Screening: Data From the Italian National Registry of Infants With Congenital Hypothyroidism Journal of Clinical Endocrinology and Metabolism, March 24, 2013 Review Article
28 Impact of vitamin D fortified milk supplementation on vitamin D status of healthy school children aged 10-14 years Osteoporosis International, March 24, 2013 Clinical Article
29 High end of normal ACTH and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study Full Text BMC Medicine, March 24, 2013
30 Comparison of the Effect of Insulin Glulisine to Insulin Aspart on Breakfast Postprandial Blood Glucose Levels in Children with Type 1 DM on Multiple Daily Injections Endocrine Practice, March 24, 2013 Clinical Article
31 Is Urolithiasis in Children Associated With Obesity or Malnutrition Journal of Renal Nutrition, March 24, 2013 Clinical Guideline
32 Congenital Hypothyroidism with Eutopic Thyroid Gland: Analysis of Clinical and Biochemical Features at Diagnosis and After Re-Evaluation Journal of Clinical Endocrinology and Metabolism, February 26, 2013 Clinical Article
As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.
Read the article summaryAs published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.
Read the article summaryAs published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.
Read the article summary1 Pacifier Restriction and Exclusive Breastfeeding Pediatrics, April 3, 2013 Review Article
2 Prebiotics in infants for prevention of allergy Cochrane Reviews, April 10, 2013 Review Article
3 The role of antibiotics in the treatment of acute rhinosinusitis in children: a systematic review Archives of Diseases in Childhood, March 8, 2013 Evidence Based Medicine
4 Association Between Total Duration of Breastfeeding and Iron Deficiency Pediatrics, April 16, 2013
5 Fish consumption in infancy and development of allergic disease up to age 12 y American Journal of Clinical Nutrition, April 11, 2013
6 Vitamin D and child health Archives of Diseases in Childhood, March 22, 2013 Review Article
7 Formula Selection for Management of Children with Cow Milk Allergy Influences the Rate of Acquisition of Tolerance: A Prospective Multicenter Study The Journal of Pediatrics, April 17, 2013 Review Article
8 Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial Pediatrics, April 8, 2013
9 Reducing the Frequency of Acute Otitis Media by Individualized Care The Pediatric Infectious Disease Journal, April 23, 2013
10 Serum vitamin D levels in children with recurrent otitis media European Archives of Oto-Rhino-Laryngology, April 1, 2013
11 White Matter Injury in Preterm Infants: Could Human Milk Play a Role in Its Prevention? Advances in Neonatal Care, April 2, 2013 Review Article
12 Prenatal Maternal Bereavement and Congenital Heart Defects in Offspring: A Registry-Based Study Pediatrics, March 26, 2013 Review Article
13 Autism before diagnosis: crying, feeding and sleeping problems in the first two years of life Acta Pediatrica, March 14, 2013 Review Article
14 Clinical signs to identify late-onset sepsis in preterm infants European Journal of Pediatrics, April 2, 2013 Review Article
15 Probiotic effects in allergic disease Journal of Paediatrics and Child Health, April 19, 2013
16 Chronic Otitis Media in Children: An Evidence-Based Guide for Diagnosis and Management Clinical Pediatrics, April 11, 2013 Review Article
17 Predicting positive food challenges in children sensitised to peanuts/tree nuts Pediatric Allergy and Immunology, April 4, 2013
18 Infant feeding practices in the first 24 to 48 hours of life in healthy term infants Acta Pediatrica, April 15, 2013 Review Article
19 The relationship between visceral fat thickness and bone mineral density in sedentary obese children and adolescents BMC Pediatrics, March 21, 2013 Free full text Review Article
20 School-age Outcomes of Extremely Preterm or Extremely Low Birth Weight Children Pediatrics, April 3, 2013 Review Article
Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more
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