Pediatrics - Pediatric Heme/Oncology News & Articles

Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology to pediatric surgery, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.

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61 LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling Frontiers in Oncology, May 2, 2013 Clinical Article

62 MicroRNAs and Recent Insights into Pediatric Ovarian Cancers Frontiers in Oncology, May 2, 2013 Clinical Article

63 Advanced Targeted, Cell and Gene-Therapy Approaches for Pediatric Hematological Malignancies: Results and Future Perspectives Frontiers in Oncology, May 2, 2013 Clinical Article

64 Incidence and risk factors for catheter-associated bloodstream infections in neonatal intensive care Acta Pediatrica, May 1, 2013 Clinical Article

65 NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia Genes, Chromosomes and Cancer, May 1, 2013 Clinical Article

66 Sickle Cell-related Bone Marrow Complications: The Utility of Diffusion-weighted Magnetic Resonance Imaging Journal of Pediatric Hematology/Oncology, May 1, 2013 Clinical Article

67 Outcome and toxicity using helical tomotherapy for craniospinal irradiation in pediatric medulloblastoma Clinical and Translational Oncology, May 1, 2013 Clinical Article

68 Medication Errors in the Home: A Multisite Study of Children With Cancer Pediatrics, April 30, 2013 Review Article

69 Minnelide reduces tumor burden in preclinical models of osteosarcoma Cancer Letters, April 30, 2013 Clinical Article

70 The relationship of body mass index and arm anthropometry to outcomes after pediatric allogeneic hematopoietic cell transplantation for hematologic malignancies Biology of Blood and Marrow Transplantation, April 30, 2013 Review Article

71 The molecular and cell biology of pediatric low-grade gliomas Oncogene, April 30, 2013 Review Article Clinical Article

72 Feasibility of an outpatient HLA haploidentical stem cell transplantation program in children using a reduced-intensity conditioning regimen and CD3-CD19 depletion Hematology, April 30, 2013 Clinical Article

73 Report of a Novel Indian Case of Congenital Erythropoietic Porphyria and Overview of Therapeutic Options Journal of Pediatric Hematology/Oncology, April 30, 2013

74 Role of NOS3 DNA Variants in Externalizing Behavioral Problems Observed in Childhood Leukemia Survivors Journal of Pediatric Hematology/Oncology, April 30, 2013 Clinical Article

75 Successful Treatment of Refractory Immune Thrombocytopenia With Rituximab in a 10-Week-Old Infant Journal of Pediatric Hematology/Oncology, April 30, 2013

76 Hydroxyurea Treatment Can Avoid the Need for Aggressive Surgery in Pediatric Fibromatosis Journal of Pediatric Hematology/Oncology, April 30, 2013 Clinical Article

77 Spontaneous rupture of an advanced pancreatoblastoma: Aberrant RASSF1A methylation and CTNNB1 mutation as molecular genetic markers Journal of Pediatric Surgery, April 29, 2013

78 NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern Leukemia, April 29, 2013 Review Article

79 Accommodation in pediatric oncology: parental experiences, preferences and unmet needs Full Text Rural and Remote Health, April 29, 2013 Review Article

80 Severe Eosinophilia in Children: A Diagnostic Dilemma Journal of Pediatric Hematology/Oncology, April 29, 2013 Clinical Article

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Clinical Pearls in Pediatrics

Having 2 or more siblings with autism spectrum disorder doubles the risk of ASD in younger children
Children with acute lymphoblastic leukemia are more susceptible to dental caries due to reduced salivary flow rate
Boys, but not girls, who are born post-term are at greater risk of adolescent obesity due to accelerated weight gain during childhood

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Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.

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Children with ?-thalassemia major at risk for premature atherosclerosis

As published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.

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HPV vaccination is not associated with increased sexual activity in adolescents

As published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.

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Most Popular Pediatrics Articles

Last month's top read Top Articles of 2012

1 Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002–2007 British Journal of Cancer, April 17, 2013 Review Article

2 Does School Attendance During Initial Cancer Treatment in Childhood Increase the Risk of Infection? Pediatric Blood & Cancer, April 4, 2013

3 Molecular Assessment of Minimal Residual Disease in PBSC Harvests Provides Prognostic Information in Neuroblastoma Pediatric Blood & Cancer, April 2, 2013

4 Weight Status of Children With Sickle Cell Disease Pediatrics, April 4, 2013

5 The Childhood Leukemia International Consortium Cancer Epidemiology, April 26, 2013 Review Article

6 A Case Study of Personalized Therapy for Osteosarcoma Pediatric Blood & Cancer, April 5, 2013

7 Risk Factors for Peripherally Inserted Central Venous Catheter Complications in Children Risk Factors for PICC Complications in Children JAMA Pediatrics, March 21, 2013

8 Readmissions for Warfarin-Related Bleeding in Pediatric Patients After Hospital Discharge Pediatric Blood & Cancer, April 22, 2013 Review Article

9 The utility of FDG PET in diagnosis and follow-up of lymphoma in childhood European Journal of Pediatrics, April 8, 2013 Review Article

10 Thoracoscopic resection of computed tomography-localized lung nodules in children Journal of Pediatric Surgery, April 23, 2013 Review Article
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11 Brain tumors in children. Time to diagnosis - a single centre experience Pediatrics International, April 1, 2013 Review Article

12 The treatment of children suffering from chronic myelogenous leukemia: A comparison of the result of treatment with imatinib mesylate and allogeneic hematopoietic stem cell transplantation Pediatric Transplantation, April 8, 2013 Review Article

13 Protein C deficiency as the major cause of thrombophilias in childhood Pediatrics International, April 1, 2013 Review Article

14 Vincristine, Irinotecan, and Temozolomide for Treatment of Relapsed Alveolar Rhabdomyosarcoma Journal of Pediatric Hematology/Oncology, April 26, 2013

15 FoxG1 Interacts with Bmi1 to Regulate Self-Renewal and Tumorigenicity of Medulloblastoma Stem Cells Stem Cells, April 19, 2013

16 Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence Pediatric Surgery International, March 28, 2013

17 Bone marrow evaluation for pediatric patients International Journal of Laboratory Hematology, April 25, 2013 Review Article

18 Epidemiology of Bloodstream Infections in Children with Sickle Cell Disease The Pediatric Infectious Disease Journal, April 25, 2013 Review Article

19 Outcome of heart transplantation in pediatric cancer survivors Pediatric Transplantation, April 8, 2013 Review Article

20 Reviewing the Follow-up Care of Pediatric Patients Status Post-Hematopoietic Stem Cell Transplantation for the Primary Care Pediatrician Clinical Pediatrics, April 11, 2013 Review Article

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more

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Pediatrics - Pediatric Heme/Oncology News & Articles

Articles

Clinical Pearls in Pediatrics

Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

Children with ?-thalassemia major at risk for premature atherosclerosis

HPV vaccination is not associated with increased sexual activity in adolescents

Most Popular Pediatrics Articles

Other Topics in Pediatrics