Pediatrics - Clinical Pharmacology News & Articles

Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology to pediatric surgery, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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121 Tolerability of Curcumin in Pediatric Inflammatory Bowel Disease: A Forced-Dose Titration Study Journal of Pediatric Gastroenterology and Nutrition, March 21, 2013 Clinical Article

122 Canakinumab in pediatric rheumatic diseases Expert Opinion on Biological Therapy, March 21, 2013 Clinical Article

123 Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: A systematic review Pediatric Transplantation, March 21, 2013 Evidence Based Medicine Clinical Article

124 Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial Pediatrics, March 20, 2013 Clinical Article

125 Racial Differences in Antibiotic Prescribing by Primary Care Pediatricians Pediatrics, March 20, 2013 Review Article

126 Glycopyrrolate and Theophylline for the Treatment of Severe Pallid Breath-holding Spells Pediatrics, March 20, 2013

127 Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children Pediatric Allergy and Immunology, March 20, 2013 Clinical Article

128 Physical compatibility of various drugs with neonatal total parenteral nutrient solution during simulated Y-site administration American Journal of Health-System Pharmacy, March 20, 2013 Clinical Article

129 Intravenous Pamidronate in the Treatment of Severe Idiopathic Infantile Hypercalcemia Iranian Journal of Kidney Diseases, March 20, 2013 Clinical Article

130 Low Morbidity and Mortality in Children with Diabetic Ketoacidosis Treated with Isotonic Fluids The Journal of Pediatrics, March 19, 2013 Review Article

131 Off-label prescribing patterns of antiemetics in children: a multicenter study in Italy European Journal of Pediatrics, March 19, 2013 Review Article

132 Alemtuzumab induction in pediatric kidney transplantation Pediatric Transplantation, March 19, 2013 Review Article
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133 Landiolol hydrochloride infusion for treatment of junctional ectopic tachycardia in post-operative paediatric patients with congenital heart defect EP Europace, March 19, 2013 Clinical Article

134 Duration of empirical antibiotic therapy for infants suspected of early-onset sepsis Current Opinion in Pediatrics, March 18, 2013 Clinical Article

135 Comparative safety of selective serotonin reuptake inhibitors among pediatric users with respect to adverse cardiac events Pharmacoepidemiology and Drug Safety, March 18, 2013 Review Article

136 Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus The Journal of Pediatrics, March 15, 2013 Review Article

137 Diverse Seizure Presentation of Acute Mycoplasma Pneumoniae Encephalitis Resolving With Immunotherapy Journal of Child Neurology, March 15, 2013

138 Medication-Related Emergency Department Visits and Hospital Admissions in Pediatric Patients: A Qualitative Systematic Review The Journal of Pediatrics, March 14, 2013 Evidence Based Medicine

139 Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange Pediatrics, March 14, 2013

140 Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD Journal of Pediatric Gastroenterology and Nutrition, March 14, 2013 Review Article

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Clinical Pearls in Pediatrics

Having 2 or more siblings with autism spectrum disorder doubles the risk of ASD in younger children
Children with acute lymphoblastic leukemia are more susceptible to dental caries due to reduced salivary flow rate
Boys, but not girls, who are born post-term are at greater risk of adolescent obesity due to accelerated weight gain during childhood

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Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.

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Children with ?-thalassemia major at risk for premature atherosclerosis

As published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.

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HPV vaccination is not associated with increased sexual activity in adolescents

As published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.

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Most Popular Pediatrics Articles

Last month's top read Top Articles of 2012

1 Update in Pediatric Anaphylaxis: A Systematic Review Clinical Pediatrics, February 27, 2013 Evidence Based Medicine

2 Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial Pediatrics, March 20, 2013

3 A Comparison of Heart Rate Changes Associated with Levalbuterol and Racemic Albuterol in Pediatric Cardiology Patients Annals of Pharmacotherapy, April 26, 2013 Review Article

4 Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections European Journal of Clinical Pharmacology, April 12, 2013

5 Low Morbidity and Mortality in Children with Diabetic Ketoacidosis Treated with Isotonic Fluids The Journal of Pediatrics, March 19, 2013 Review Article

6 Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

7 Probiotic effects in allergic disease Journal of Paediatrics and Child Health, April 19, 2013

8 Pyloromyotomy versus intravenous atropine therapy for the treatment of infantile pyloric stenosis: an analysis using nationwide hospital discharge database Pediatrics International, April 1, 2013 Review Article

9 The safety of cefepime and ceftazidime in pediatric oncology patients Pediatric Blood & Cancer, February 22, 2013

10 Cold Preparation Use in Young Children After FDA Warnings: Do Concerns Still Exist? Clinical Pediatrics, April 1, 2013 Review Article

11 Auvi-Q Versus EpiPen: Preferences of Adults, Caregivers, and Children The Journal of Allergy and Clinical Immunology: In Practice, April 12, 2013

12 Commencement of warfarin therapy in children following the Fontan procedure Thrombosis Research, April 17, 2013

13 Variation in the Use of Diuretic Therapy for Infants With Bronchopulmonary Dysplasia Pediatrics, April 9, 2013

14 Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

15 Paracetamol to induce ductus arteriosus closure: is it valid? Archives of Diseases in Childhood, April 22, 2013 Review Article

16 Is prophylactic atropine necessary during ketamine sedation in children? Journal of Paediatrics and Child Health, March 27, 2013

17 Time and Risk Preferences and the Use of Asthma Controller Medication Pediatrics, April 5, 2013 Review Article

18 Role of methotrexate in juvenile idiopathic arthritis: where we have been and where we are going International Journal of Clinical Rheumatology, April 17, 2013 Review Article

19 Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange Pediatrics, February 28, 2013

20 The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery Annals of Cardiac Anaesthesia, April 2, 2013 Free full text

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more

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Pediatrics - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Pediatrics

Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

Children with ?-thalassemia major at risk for premature atherosclerosis

HPV vaccination is not associated with increased sexual activity in adolescents

Most Popular Pediatrics Articles

Other Topics in Pediatrics