Pediatrics - Clinical Pharmacology News & Articles

Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology, pediatric surgery, to General Pediatric News, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.

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Latest Full Text Articles (106) Focus on Neurologic Disorders

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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961 Targeting Airway Inflammation in Cystic Fibrosis in Children: Past, Present, and Future Pediatric Drugs, April 21, 2011

962 Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants ADC Fetal & Neonatal Edition, April 21, 2011

963 Evaluation of 4 Weeks Neonatal Antiretroviral Prophylaxis as a Component of a Prevention of Mother-to-child Transmission Program in a Resource-rich Setting The Pediatric Infectious Disease Journal, April 21, 2011

964 Dose escalation of intravenous irinotecan using oral cefpodoxime: A phase I study in pediatric patients with refractory solid tumors Pediatric Blood & Cancer, April 21, 2011

965 Intravitreal bevacizumab in retinopathy of prematurity: an interventional case series Graefe's Archive for Clinical and Experimental Ophthalmology, April 20, 2011 Clinical Article

966 Investigation of the safety of oseltamivir in infants less than 1 year of age infected with influenza, 2003/2004 season in Japan Journal of Pediatric Infectious Diseases, April 20, 2011

967 Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanercept The Journal of Rheumatology, April 19, 2011 Clinical Article

968 Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia but is not improved with gemtuzumab ozogamicin Blood, April 19, 2011 Clinical Article

969 Etanercept in the treatment of disease-modifying anti-rheumatic drug (DMARD)-refractory polyarticular course juvenile idiopathic arthritis: Experience from Japanese clinical trials Modern Rheumatology, April 19, 2011 Clinical Article

970 Vancomycin Resistant Enterococci outbreak in neonatal unit and management of cases after discharge Journal of Pediatric Infectious Diseases, April 19, 2011

971 Fluconazole Loading Dose Pharmacokinetics and Safety in Infants The Pediatric Infectious Disease Journal, April 18, 2011

972 Trihexyphenidyl Improves Motor Function in Children With Dystonic Cerebral Palsy: A Retrospective Analysis Journal of Child Neurology, April 18, 2011

973 Pentostatin for treatment of refractory autoimmune lymphoproliferative syndrome Pediatric Blood & Cancer, April 15, 2011

974 Novel multidrug therapy for children with cyclosporine-resistant or -intolerant nephrotic syndrome Pediatric Nephrology, April 14, 2011 Clinical Article

975 High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation Pediatric Blood & Cancer, April 14, 2011

976 Piperacillin/tazobactam versus cefozopran for the empirical treatment of pediatric cancer patients with febrile neutropenia Pediatric Blood & Cancer, April 14, 2011

977 Ganciclovir treatment in children: evidence of subtherapeutic levels International Journal of Antimicrobial Agents, April 13, 2011

978 Improved Outcomes Associated With Intraoperative Steroid Use in High-Risk Pediatric Cardiac Surgery Full Text Annals of Thoracic Surgery, April 13, 2011

979 Sirolimus for the treatment of complicated vascular anomalies in children Pediatric Blood & Cancer, April 13, 2011

980 Levofloxacin for the treatment of Mycoplasma pneumoniae-associated meningoencephalitis in childhood International Journal of Antimicrobial Agents, April 13, 2011

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Clinical Pearls in Pediatrics

Having 2 or more siblings with autism spectrum disorder doubles the risk of ASD in younger children
Children with acute lymphoblastic leukemia are more susceptible to dental caries due to reduced salivary flow rate
Boys, but not girls, who are born post-term are at greater risk of adolescent obesity due to accelerated weight gain during childhood

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Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.

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Children with ?-thalassemia major at risk for premature atherosclerosis

As published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.

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HPV vaccination is not associated with increased sexual activity in adolescents

As published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.

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Most Popular Pediatrics Articles

Last month's top read Top Articles of 2012

1 Association of CYP2C19 Polymorphisms and Lansoprazole-Associated Respiratory Adverse Effects in Children The Journal of Pediatrics, April 30, 2013

2 Incidence of Rash After Amoxicillin Treatment in Children With Infectious Mononucleosis Pediatrics, May 2, 2013

3 Does the Use of Antipyretics in Children Who Have Acute Infections Prolong Febrile Illness? A Systematic Review and Meta-Analysis The Journal of Pediatrics, May 10, 2013 Evidence Based Medicine

4 Use of Zoledronic Acid for Treatment of Chemotherapy Related Osteonecrosis in Children and Adolescents: A Retrospective Analysis Pediatric Blood & Cancer, May 16, 2013 Review Article

5 Dexibuprofen for fever in children with upper respiratory tract infection Pediatrics International, May 21, 2013

6 Safety of perinatal exposure to antiretroviral medications: developmental outcomes in infants The Pediatric Infectious Disease Journal, May 23, 2013 Review Article

7 Cold Preparation Use in Young Children After FDA Warnings: Do Concerns Still Exist? Clinical Pediatrics, April 1, 2013 Review Article

8 The safety of statins in children Acta Pediatrica, May 1, 2013 Review Article

9 Clinicians Views on Antiepileptic Medication Management in Nonepileptic Seizures Journal of Child Neurology, May 17, 2013

10 Auvi-Q Versus EpiPen: Preferences of Adults, Caregivers, and Children The Journal of Allergy and Clinical Immunology: In Practice, April 12, 2013

11 Influence of "GERD" Label on Parents’ Decision to Medicate Infants Pediatrics, May 6, 2013 Review Article

12 An update on pediatric hospital-based sedation Current Opinion in Pediatrics, May 14, 2013 Review Article

13 The clinical impact of switching attention hyperactivity disorder patients from OROS-MPH to Novo-MPH ER-C: A paediatric practice review Paediatrics & Child Health, February 20, 2013 Review Article

14 Efficacy and Safety of Whole Body Skin Cleansing With Chlorhexidine in Neonates—A Systemic Review The Pediatric Infectious Disease Journal, May 20, 2013 Evidence Based Medicine

15 Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence Pediatric Surgery International, March 28, 2013

16 Adrenocorticotropic Hormone for the Treatment of West Syndrome in Children Annals of Pharmacotherapy, April 29, 2013

17 High Rates of Resolution of Cholestasis in Parenteral Nutrition-Associated Liver Disease with Fish Oil-Based Lipid Emulsion Monotherapy The Journal of Pediatrics, December 10, 2012

18 Trough Concentrations of Vancomycin: Adult Therapeutic Targets Are Not Appropriate for Children The Pediatric Infectious Disease Journal, December 10, 2012

19 The utility of sildenafil in pulmonary hypertension: a focus on bronchopulmonary dysplasia Archives of Diseases in Childhood, May 7, 2013 Review Article

20 Serum ibuprofen levels of extremely preterm infants treated prophylactically with oral ibuprofen to prevent patent ductus arteriosus European Journal of Clinical Pharmacology, May 6, 2013

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more

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Pediatrics - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Pediatrics

Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

Children with ?-thalassemia major at risk for premature atherosclerosis

HPV vaccination is not associated with increased sexual activity in adolescents

Most Popular Pediatrics Articles

Other Topics in Pediatrics