Pediatrics - Clinical Pharmacology News & Articles

Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology to pediatric surgery, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.

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921 Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia but is not improved with gemtuzumab ozogamicin Blood, April 19, 2011 Clinical Article

922 Etanercept in the treatment of disease-modifying anti-rheumatic drug (DMARD)-refractory polyarticular course juvenile idiopathic arthritis: Experience from Japanese clinical trials Modern Rheumatology, April 19, 2011 Clinical Article

923 Vancomycin Resistant Enterococci outbreak in neonatal unit and management of cases after discharge Journal of Pediatric Infectious Diseases, April 19, 2011

924 Fluconazole Loading Dose Pharmacokinetics and Safety in Infants The Pediatric Infectious Disease Journal, April 18, 2011

925 Trihexyphenidyl Improves Motor Function in Children With Dystonic Cerebral Palsy: A Retrospective Analysis Journal of Child Neurology, April 18, 2011

926 Pentostatin for treatment of refractory autoimmune lymphoproliferative syndrome Pediatric Blood & Cancer, April 15, 2011

927 Novel multidrug therapy for children with cyclosporine-resistant or -intolerant nephrotic syndrome Pediatric Nephrology, April 14, 2011 Clinical Article

928 High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation Pediatric Blood & Cancer, April 14, 2011

929 Piperacillin/tazobactam versus cefozopran for the empirical treatment of pediatric cancer patients with febrile neutropenia Pediatric Blood & Cancer, April 14, 2011

930 Ganciclovir treatment in children: evidence of subtherapeutic levels International Journal of Antimicrobial Agents, April 13, 2011

931 Improved Outcomes Associated With Intraoperative Steroid Use in High-Risk Pediatric Cardiac Surgery Full Text Annals of Thoracic Surgery, April 13, 2011

932 Sirolimus for the treatment of complicated vascular anomalies in children Pediatric Blood & Cancer, April 13, 2011

933 Levofloxacin for the treatment of Mycoplasma pneumoniae-associated meningoencephalitis in childhood International Journal of Antimicrobial Agents, April 13, 2011

934 Inhaled Beta-2 Agonist Salbutamol for the Treatment of Transient Tachypnea of the Newborn The Journal of Pediatrics, April 13, 2011

935 Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study Acta Pediatrica, April 12, 2011

936 Lung function changes in asthmatic children treated with HFA-BDP Pediatric Pulmonology, April 7, 2011

937 Rituximab in combination with multiagent chemotherapy for Pediatric follicular lymphoma Pediatric Blood & Cancer, April 7, 2011

938 Increase of Streptococcus pneumoniae serotype 6C at 8 children's hospitals in the United States from 1993-2009 Journal of Clinical Microbiology, April 6, 2011

939 Propofol for procedural sedation/anaesthesia in neonates Cochrane Reviews, April 6, 2011

940 Mycophenolate mofetil monotherapy in the management of paediatric uveitis Eye, April 5, 2011 Continuing Medical Education Clinical Article

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Clinical Pearls in Pediatrics

Having 2 or more siblings with autism spectrum disorder doubles the risk of ASD in younger children
Children with acute lymphoblastic leukemia are more susceptible to dental caries due to reduced salivary flow rate
Boys, but not girls, who are born post-term are at greater risk of adolescent obesity due to accelerated weight gain during childhood

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Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.

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Children with ?-thalassemia major at risk for premature atherosclerosis

As published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.

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HPV vaccination is not associated with increased sexual activity in adolescents

As published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.

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Most Popular Pediatrics Articles

Last month's top read Top Articles of 2012

1 Update in Pediatric Anaphylaxis: A Systematic Review Clinical Pediatrics, February 27, 2013 Evidence Based Medicine

2 Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial Pediatrics, March 20, 2013

3 A Comparison of Heart Rate Changes Associated with Levalbuterol and Racemic Albuterol in Pediatric Cardiology Patients Annals of Pharmacotherapy, April 26, 2013 Review Article

4 Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections European Journal of Clinical Pharmacology, April 12, 2013

5 Low Morbidity and Mortality in Children with Diabetic Ketoacidosis Treated with Isotonic Fluids The Journal of Pediatrics, March 19, 2013 Review Article

6 Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

7 Probiotic effects in allergic disease Journal of Paediatrics and Child Health, April 19, 2013

8 Pyloromyotomy versus intravenous atropine therapy for the treatment of infantile pyloric stenosis: an analysis using nationwide hospital discharge database Pediatrics International, April 1, 2013 Review Article

9 The safety of cefepime and ceftazidime in pediatric oncology patients Pediatric Blood & Cancer, February 22, 2013

10 Cold Preparation Use in Young Children After FDA Warnings: Do Concerns Still Exist? Clinical Pediatrics, April 1, 2013 Review Article

11 Auvi-Q Versus EpiPen: Preferences of Adults, Caregivers, and Children The Journal of Allergy and Clinical Immunology: In Practice, April 12, 2013

12 Commencement of warfarin therapy in children following the Fontan procedure Thrombosis Research, April 17, 2013

13 Variation in the Use of Diuretic Therapy for Infants With Bronchopulmonary Dysplasia Pediatrics, April 9, 2013

14 Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

15 Paracetamol to induce ductus arteriosus closure: is it valid? Archives of Diseases in Childhood, April 22, 2013 Review Article

16 Is prophylactic atropine necessary during ketamine sedation in children? Journal of Paediatrics and Child Health, March 27, 2013

17 Time and Risk Preferences and the Use of Asthma Controller Medication Pediatrics, April 5, 2013 Review Article

18 Role of methotrexate in juvenile idiopathic arthritis: where we have been and where we are going International Journal of Clinical Rheumatology, April 17, 2013 Review Article

19 Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange Pediatrics, February 28, 2013

20 The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery Annals of Cardiac Anaesthesia, April 2, 2013 Free full text

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more

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Pediatrics - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Pediatrics

Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

Children with ?-thalassemia major at risk for premature atherosclerosis

HPV vaccination is not associated with increased sexual activity in adolescents

Most Popular Pediatrics Articles

Other Topics in Pediatrics