Pediatrics - Clinical Pharmacology News & Articles

Exclusive content related to your pediatric, neonatal and adolescent patients is now available on MDLinx Pediatrics! Not only can you find numerous clinical pearls taken from recent daily competitive and Physician Review quizzes from the Smartest Pediatrician, but also a shortcut to keeping current with the highlights written by D. Scott Cunningham, MD, PhD, for the “can’t miss” articles published in your field. MDLinx Pediatrics is a premier service, complimentary for healthcare professionals, that sorts, ranks and summarizes the literature that’s relevant to your specialty and subspecialty. From adolescent medicine to radiology, neonatology to pediatric surgery, we have the coverage you need to stay on top of the ever-changing practice of pediatric medicine.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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841 Mixtures of Oseltamivir-sensitive and -resistant Pandemic Influenza A/H1N1/2009 Viruses in Immunocompromised Hospitalized Children The Pediatric Infectious Disease Journal, July 5, 2011

842 2009 Influenza A H1N1 Infections: Delays in Starting Treatment With Oseltamivir Were Associated With a More Severe Disease The Pediatric Infectious Disease Journal, July 5, 2011

843 Safety and efficacy of rituximab in severe juvenile dermatomyositis: Results from 9 patients from the french autoimmunity and rituximab registry The Journal of Rheumatology, July 1, 2011 Clinical Article

844 Socioeconomic Status and the Likelihood of Antibiotic Treatment for Signs and Symptoms of Pulmonary Exacerbation in Children with Cystic Fibrosis The Journal of Pediatrics, July 1, 2011

845 Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis Modern Rheumatology, July 1, 2011 Clinical Article

846 Effects of Creatine Supplementation in Rett Syndrome: A Randomized, Placebo-Controlled Trial Journal of Developmental and Behavioral Pediatrics, June 30, 2011 Clinical Article

847 High-dose fenoldopam reduces post operative neutrophil gelatinase associated lipocaline and cystatin C levels in pediatric cardiac surgery Critical Care, June 30, 2011

848 Clinical outcomes after withdrawal of anti-tumor necrosis factor-alpha therapy in juvenile idiopathic arthritis: A twelve-year experience Arthritis & Rheumatism, June 30, 2011 Clinical Article

849 The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study Full Text PLoS Medicine, June 30, 2011

850 Trends in Sunscreen Use Among U.S. High School Students: 1999-2009 Journal of Adolescent Health, June 30, 2011 Clinical Article

851 Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: A children's oncology group study Full Text Clinical Cancer Research, June 29, 2011

852 Vitamin D Supplementation and Status in Infants: A Prospective Cohort Observational Study Journal of Pediatric Gastroenterology and Nutrition, June 29, 2011

853 Oral Choline Supplementation in Children With Intestinal Failure Journal of Pediatric Gastroenterology and Nutrition, June 29, 2011 Clinical Article

854 Oxaliplatin, Irinotecan, and Gemcitabine: A Novel Combination in the Therapy of Progressed, Relapsed, or Refractory Tumors in Children Journal of Pediatric Hematology/Oncology, June 28, 2011 Clinical Article

855 Combined treatment for child refractory Mycoplasma pneumoniae Pneumonia with ciprofloxacin and glucocorticoid Pediatric Pulmonology, June 28, 2011 Clinical Article

856 Safety and Efficacy of High-dose Acarbose Treatment for Dumping Syndrome Journal of Pediatric Gastroenterology and Nutrition, June 28, 2011 Clinical Article

857 Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors Full Text Journal of Clinical Oncology, June 28, 2011

858 The increasing prevalence of clindamycin resistance in Staphylococcus aureus isolates in children with head and neck abscesses Canadian Journal of Infectious Diseases & Medical Microbiology, June 28, 2011

859 An Evaluation of Using Population Pharmacokinetic Models to Estimate Pharmacodynamic Parameters for Propofol and Bispectral Index in Children Full Text Anesthesiology, June 28, 2011

860 The Influence of Valproic Acid and Carbamazepine Treatment on Serum Biotin and Zinc Levels and on Biotinidase Activity Journal of Child Neurology, June 27, 2011 Clinical Article

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Clinical Pearls in Pediatrics

Having 2 or more siblings with autism spectrum disorder doubles the risk of ASD in younger children
Children with acute lymphoblastic leukemia are more susceptible to dental caries due to reduced salivary flow rate
Boys, but not girls, who are born post-term are at greater risk of adolescent obesity due to accelerated weight gain during childhood

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Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

As published in Clinical Orthopedics and Related Research, elevated BMI is associated with fractures of the foot, ankle, knee, and leg (but not femur or hip) in children. In overweight, moderately obese, and extremely obese children, the ORs for fractures of the foot were 1.14, 1.23, and 1.42, respectively; fractures of the ankle, knee, and leg were 1.27, 1.28, and 1.51, respectively. Children 6-11 years of age were at highest risk.

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Children with ?-thalassemia major at risk for premature atherosclerosis

As published in the Journal of Pediatric Hematology/Oncology, children with ?-thalassemia major (n=31; age range, 4-16 y) exhibit laboratory and ultrasound evidence of premature atherosclerosis. Specifically, total cholesterol, LDL-C, HDL-C, and nitrate/nitrite levels were decreased, and VLDL-C levels, chitotroisidase activity, and carotid IMT were increased in affected children.

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HPV vaccination is not associated with increased sexual activity in adolescents

As published in Pediatrics, adolescent girls (11-12 years of age) vaccinated with HPV were not shown to have increased sexual activity over 3 years of follow-up compared to non-vaccinated girls (adjusted incidence rate ratio = 1.29). Sexual activity was assessed based on pregnancy, STD testing or diagnosis, and contraceptive counseling.

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Most Popular Pediatrics Articles

Last month's top read Top Articles of 2012

1 Update in Pediatric Anaphylaxis: A Systematic Review Clinical Pediatrics, February 27, 2013 Evidence Based Medicine

2 Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial Pediatrics, March 20, 2013

3 A Comparison of Heart Rate Changes Associated with Levalbuterol and Racemic Albuterol in Pediatric Cardiology Patients Annals of Pharmacotherapy, April 26, 2013 Review Article

4 Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections European Journal of Clinical Pharmacology, April 12, 2013

5 Low Morbidity and Mortality in Children with Diabetic Ketoacidosis Treated with Isotonic Fluids The Journal of Pediatrics, March 19, 2013 Review Article

6 Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

7 Probiotic effects in allergic disease Journal of Paediatrics and Child Health, April 19, 2013

8 Pyloromyotomy versus intravenous atropine therapy for the treatment of infantile pyloric stenosis: an analysis using nationwide hospital discharge database Pediatrics International, April 1, 2013 Review Article

9 The safety of cefepime and ceftazidime in pediatric oncology patients Pediatric Blood & Cancer, February 22, 2013

10 Cold Preparation Use in Young Children After FDA Warnings: Do Concerns Still Exist? Clinical Pediatrics, April 1, 2013 Review Article

11 Auvi-Q Versus EpiPen: Preferences of Adults, Caregivers, and Children The Journal of Allergy and Clinical Immunology: In Practice, April 12, 2013

12 Commencement of warfarin therapy in children following the Fontan procedure Thrombosis Research, April 17, 2013

13 Variation in the Use of Diuretic Therapy for Infants With Bronchopulmonary Dysplasia Pediatrics, April 9, 2013

14 Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants Cochrane Reviews, April 15, 2013 Evidence Based Medicine

15 Paracetamol to induce ductus arteriosus closure: is it valid? Archives of Diseases in Childhood, April 22, 2013 Review Article

16 Is prophylactic atropine necessary during ketamine sedation in children? Journal of Paediatrics and Child Health, March 27, 2013

17 Time and Risk Preferences and the Use of Asthma Controller Medication Pediatrics, April 5, 2013 Review Article

18 Role of methotrexate in juvenile idiopathic arthritis: where we have been and where we are going International Journal of Clinical Rheumatology, April 17, 2013 Review Article

19 Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange Pediatrics, February 28, 2013

20 The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery Annals of Cardiac Anaesthesia, April 2, 2013 Free full text

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatrics more

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Pediatrics - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Pediatrics

Highlights in Pediatrics

Elevated BMI associated with lower extremity fractures in children

Children with ?-thalassemia major at risk for premature atherosclerosis

HPV vaccination is not associated with increased sexual activity in adolescents

Most Popular Pediatrics Articles

Other Topics in Pediatrics