The Latest Clinical Articles in Pediatrics and Children's Health

1Neonatal sepsis in a rapidly growing, tertiary neonatal intensive care unit: Trends over 18 yearsPediatrics International, March 30, 2015  Clinical Article
2Systematic review and meta-analysis of objective and subjective quality of life among pediatric, adolescent, and young adult bone tumor survivorsPediatric Blood & Cancer, March 30, 2015  Review Article
3L-Asparaginase lowers plasma antithrombin and mannan-binding-lectin levels: Impact on thrombotic and infectious events in children with acute lymphoblastic leukemiaPediatric Blood & Cancer, March 30, 2015  Clinical Article
4Incidence rates of atopic dermatitis, asthma, and allergic rhinoconjunctivitis in Danish and Swedish childrenThe Journal of Allergy and Clinical Immunology, March 30, 2015  Clinical Article
5School performance and alcohol-related disorders in early adulthood: A Swedish national cohort studyInternational Journal of Epidemiology, March 30, 2015  Clinical Article
6Management of severe paediatric malaria in resource-limited settingsBMC Medicine, March 30, 2015  Full Text  Review Article
7Healthcare burden of venous thromboembolism in childhood chronic renal diseasesPediatric Nephrology, March 30, 2015  Clinical Article
8Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytesHepatology, March 30, 2015  Clinical Article
9Assessment of 35 children with abdominal tuberculosisThe Turkish Journal of Gastroenterology, March 30, 2015  Full Text  Review Article
10Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: A six months post-treatment follow-up studyMalaria Journal, March 30, 2015  Full Text  Clinical Article
1More than a third of 12-year-olds embarrassed to smile because of their teethUniversity College London New, March 30, 2015
2New insight into tackling poor oral health in children around the globeUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
3Ebola test vaccines appear safe in phase 2 Liberian clinical trialNIH News, March 27, 2015
4Peoples health at the centre of new global blueprint to reduce disaster risksWHO - World Health Organization, March 26, 2015
5WHO and World Food Programme join forces to reach zero Ebola casesWHO - World Health Organization, March 26, 2015
6FDA Drug Safety Communication: FDA warns of serious slowing of the heart rate when antiarrhythmic drug amiodarone is used with hepatitis C treatments containing sofosbuvir (Harvoni or Sovaldi) in combination with another direct acting antiviral drugFDA What's New: Drugs, March 26, 2015
7Risk factors associated with overweight cluster already in children University of Eastern Finland News, March 26, 2015
8First Ebola vaccine to be tested in affected communities one year into outbreak: Ring vaccination starts in Coyah, GuineaWHO news, March 26, 2015
9American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
10For most children with HIV and low immune cell count, cells rebound after treatmentNIH News, March 24, 2015

Show Me:

Cortisol as a biomarker of obstructive sleep apnea

As reported in Pediatric Pulmonology, salivary cortisol has an increased diurnal variation in children with mild or moderate-to-severe obstructive sleep apnea, while no changes in α-amylase were detected.

5-HT levels elevated in autism

As reported in European Neuropsychopharmacology, based on a meta-analysis of 22 studies, serotonin (5-HT) levels are significantly elevated in the whole blood of children with autism (OR = 4.6).

Narrow-spectrum antibiotics recommended for CAP in children

As reported in Pediatrics, narrow-spectrum antibiotics yielded similar outcomes in children with community-acquired pneumonia (CAP) to broad-spectrum antibiotics. The study was conducted in 4 hospital and involved 492 patients between 2 months and 18 years with a discharge diagnosis of CAP. Other than a 10-hour decrease in length of stay in the narrow-spectrum antibiotic groups, the outcomes were similar between the narrow- and broad-spectrum antibiotic groups.

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Clinical Pearls

Clinical Pearl from Smartest DocLong-term pediatric ventricular assist device support as a bridge to heart transplantation does not seem to affect long-term quality of life.

Clinical Pearl from Smartest DocBoth selenium and zinc are significantly decreased in the children with idiopathic intractable epilepsy.

Clinical Pearl from Smartest DocKicks and strikes from a knee are common causes of soccer-related injury in children and teens.

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