Effects of agressive parenteral nutrition on growth and clinical outcome in preterm infants
Pediatrics International, 08/17/2012
Can E et al. – Aggressive PN strategy seems to positively affect the neonates’ anthropometric measurements at 40th gestational week and the development of ROP.
Methods- Fifty three neonates born <34GWs and hospitalized in NICU were included in this prospective study.
- They were randomly divided into two groups.
- The Ist-Group received aggressive parenteral nutrition(PN)(amino acids administered 3 g/kg/day and lipids 2 g/kg/day on 1stday of life).
- The 2nd-Group received conventional PN(amino acids administered 1.5 g/kg/day and lipids 1 g/kg/day on 1stday of life).
- The anthropometric measurements, clinical outcomes and serum levels of IGF-I, IGFBPs and thyroid hormones were compared between groups.
- At 40th week of gestation, the measurements of height and head circumference and serum levels of IGF-I and IGFBP3 were statistically higher in the group receiving aggressive PN.
- Thyroid hormones were not affected by aggressive PN.
- The lower levels of IGF-I and IGFBP3 in the group receiving conventional PN were negatively correlated with development of ROP.
