Does attention-deficit-hyperactivity disorder exacerbate executive dysfunction in children with neurofibromatosis type 1
Developmental Medicine & Child Neurology, 08/08/2012
Payne JM et al. – Executive dysfunction occurs with the same severity in children with neurofibromatosis type 1 (NF1), whether or not they have a comorbid diagnosis of attention–deficit–hyperactivity disorder (ADHD), suggesting that executive impairments are not unique contributors to ADHD symptomatology in NF1. The findings are discussed within the context of recent evidence in Nf1 optic glioma (OPG) experimental model, in which a mechanistic connection between NF1 gene expression, executive system failure, and dopaminergic pathway integrity has been established.