Progressive transformation of germinal centers in children and adolescents: An intriguing cause of lymphadenopathy
Pediatric Blood & Cancer, 06/22/2012
Shaikh F et al. – Progressive transformation of germinal centers (PTGC) is a nonspecific manifestation of a variety of associated conditions. There is a small risk of subsequent HL, and a larger risk of requiring multiple biopsies for recurrent PTGC. The presence of an immune disorder should be considered in patients who present with generalized lymphadenopathy, splenomegaly, immune cytopenias, and/or progression to HL. Routine surveillance imaging may not be required.