A Randomized, Prospective, Comparison Study of a Mixture of Acacia Fiber, Psyllium Fiber, and Fructose vs Polyethylene Glycol 3350 with Electrolytes for the Treatment of Chronic Functional Constipation in Childhood
The Journal of Pediatrics, 06/12/2012
Quitadamo P et al. – In this randomized study, they did not find any significant difference between the efficacy of acacia fiber, psyllium fiber, and fructose (AFPFF) and PEG+E in the treatment of children with CFC. Both medications were proved to be safe for CFC treatment, but PEG+E was better accepted by children.
This was a randomized, open label, prospective, controlled, parallel-group study involving 100 children who were diagnosed with CFC according to the Rome III Criteria.
Children were randomly divided into 2 groups: 50 children received AFPFF (16.8 g daily) and 50 children received PEG+E (0.5 g/kg daily) for 8 weeks.
Primary outcome measures were frequency of bowel movements, stool consistency, fecal incontinence, and improvement of other associated gastrointestinal symptoms.
Safety was assessed with evaluation of clinical adverse effects and growth measurements.
Compliance rates were 72% for AFPFF and 96% for PEG+E. A significant improvement of constipation was seen in both groups.
After 8 weeks, 77.8% of children treated with AFPFF and 83% of children treated with PEG+E had improved (P = .788).
Neither PEG+E nor AFPFF caused any clinically significant side effects during the entire course of the study period.
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