A Randomized, Prospective, Comparison Study of a Mixture of Acacia Fiber, Psyllium Fiber, and Fructose vs Polyethylene Glycol 3350 with Electrolytes for the Treatment of Chronic Functional Constipation in Childhood
The Journal of Pediatrics,

Quitadamo P et al. – In this randomized study, they did not find any significant difference between the efficacy of acacia fiber, psyllium fiber, and fructose (AFPFF) and PEG+E in the treatment of children with CFC. Both medications were proved to be safe for CFC treatment, but PEG+E was better accepted by children.

Methods
  • This was a randomized, open label, prospective, controlled, parallel-group study involving 100 children who were diagnosed with CFC according to the Rome III Criteria.
  • Children were randomly divided into 2 groups: 50 children received AFPFF (16.8 g daily) and 50 children received PEG+E (0.5 g/kg daily) for 8 weeks.
  • Primary outcome measures were frequency of bowel movements, stool consistency, fecal incontinence, and improvement of other associated gastrointestinal symptoms.
  • Safety was assessed with evaluation of clinical adverse effects and growth measurements.

Results
  • Compliance rates were 72% for AFPFF and 96% for PEG+E. A significant improvement of constipation was seen in both groups.
  • After 8 weeks, 77.8% of children treated with AFPFF and 83% of children treated with PEG+E had improved (P = .788).
  • Neither PEG+E nor AFPFF caused any clinically significant side effects during the entire course of the study period.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pediatrics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pediatrics Articles

1 The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double-blind placebo-controlled trial Pediatric Pulmonology, July 3, 2014    Clinical Article

2 The associations between yogurt consumption, diet quality, and metabolic profiles in children in the USA European Journal of Nutrition, July 22, 2014    Clinical Article

3 Efficacy and safety of Saccharomyces boulardii for acute diarrhea Pediatrics, July 9, 2014    Evidence Based Medicine    Review Article

4 Efficacy of nebulised budesonide versus oral prednisolone in acute severe asthma The Indian Journal of Pediatrics, June 11, 2014    Clinical Article

5 A double-blind randomized trial of fish oil to lower triglycerides and improve cardiometabolic risk in adolescents The Journal of Pediatrics, July 11, 2014    Clinical Article

6 Vitamin D and fetal-neonatal calcium homeostasis: Findings from a randomized controlled trial of high-dose antenatal vitamin D supplementation Pediatric Research, July 28, 2014    Clinical Article

7 New forms of allergy immunotherapy for rhinitis and asthma Allergy and Asthma Proceedings, July 7, 2014    Clinical Article

8 Growth after adenotonsillectomy for obstructive sleep apnea: An RCT Pediatrics, July 30, 2014    Clinical Article

9 Lactobacilli and bifidobacteria in human breast milk: Influence of antibiotherapy and other host and clinical factors Journal of Pediatric Gastroenterology and Nutrition, July 14, 2014    Clinical Article

10 Prophylactic Use of Lactobacillus acidophilus/Bifidobacterium infantis Probiotics and Outcome in Very Low Birth Weight Infants The Journal of Pediatrics, June 6, 2014    Clinical Article

11 Efficacy and safety of Saccharomyces Boulardii for acute diarrhea Pediatrics, June 25, 2014    Evidence Based Medicine    Review Article

12 Omega-3 long-chain polyunsaturated fatty acids for extremely preterm infants: A systematic review Pediatrics, July 2, 2014    Evidence Based Medicine    Review Article

13 Prebiotics in healthy infants and children for prevention of acute infectious diseases: A systematic review and meta-analysis Nutrition Reviews, June 26, 2014    Evidence Based Medicine    Review Article

14 Dexamethasone for acute asthma exacerbations in children: A meta-analysis Full Text Pediatrics, March 3, 2014    Free full text    Evidence Based Medicine    Review Article

15 Effect of cod liver oil supplementation on the stearoyl-CoA desaturase index in obese children: A pilot study Obesity Research & Clinical Practice, July 24, 2014    Clinical Article

16 Impact of dietary macronutrient distribution on BMI and cardiometabolic outcomes in overweight and obese children and adolescents: A systematic review Nutrition Reviews, July 1, 2014    Evidence Based Medicine    Review Article

17 Gross motor deficits in children prenatally exposed to alcohol: a meta-analysis Pediatrics, July 10, 2014    Evidence Based Medicine    Review Article

18 Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency Hormone Research in Paediatrics, July 29, 2014    Clinical Article

19 Probiotic supplementation in preterm infants: It is time to change practice The Journal of Pediatrics, February 12, 2014    Clinical Article

20 Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children American Journal of Respiratory and Critical Care Medicine, July 8, 2014    Clinical Article

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatricsmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close