Early initiation of arginine vasopressin infusion in neonates after complex cardiac surgery
Pediatric Critical Care, 05/15/2012
Alten JA et al. – Low–dose arginine vasopressin infusion initiated in the operating room after complex neonatal cardiac surgery was associated with decreased fluid resuscitation and catecholamine requirements in the first 24 postoperative hours.Methods
- Nineteen patients that received low-dose arginine vasopressin infusion instituted in the operating room (arginine vasopressin+) were compared to 18 patients that did not receive early arginine vasopressin infusion (arginine vasopressin-).
- When comparing arginine vasopressin+ and arginine vasopressin- in the first 24hrs after cardiovascular intensive care unit admission, there was no difference in demographic variables, heart rate, blood pressure, central venous pressure, maximum lactate, maximum arterial and central venous saturation difference, urine output, chest tube output, or peritoneal drain output.
- Mean fluid resuscitation in the first 24hrs was significantly lower in the arginine vasopressin+group compared to the arginine vasopressin- group (182±61mL/kg vs. 223±53mL/kg, p=.03).
- The arginine vasopressin+ group also reached median net negative cumulative fluid balance sooner (55hrs: interquartile range 45, 74 vs. 76hrs: interquartile range 69, 92; p=.02).
- Median maximum inotrope score in the first 24hrs was significantly lower in arginine vasopressin+(9: interquartile range 5, 12.5 vs. 16.5: interquartile range 10.3, 22.1; p=.02).
- There was a nonsignificant trend toward shorter duration of mechanical ventilation and cardiovascular intensive care unit length of stay in the arginine vasopressin+ group.
- The lowest serum sodium in the first 48hrs was significantly lower in arginine vasopressin+ (132 vs. 137mmol/L, p=.01).