Pediatric tuberculosis: new guidelines and recommendations
Current Opinion in Pediatrics, 05/16/2012
Perez–Velez CM – These new guidelines have significant implications for improving pediatric TB care. Regarding diagnosis, current interferon–gamma release assays should not replace tuberculin skin testing, but may be complementary; a polymerase chain reaction assay has been validated for detecting Mycobacterium tuberculosis and rifampicin resistance in microscopy–negative samples, especially in HIV–infected and drug–resistant TB (DR–TB) suspects; and a molecular line probe assay has been validated for detecting DR–TB in microscopy–positive samples and culture isolates in DR–TB suspects.
To discuss the recommendations pertaining to infants, children, and adolescents in new and updated tuberculosis (TB) guidelines that have been published since 2010 - with emphasis on those from supranational organizations.
The main developments in the guidelines covered in this article are related to: novel diagnostics for TB infection, disease, and drug resistance; updated treatment regimens for childhood and drug-resistant TB (DR-TB); and primary and secondary prevention of TB disease in HIV-infected children and adolescents.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.