A Potential New Method to Estimate Tissue Cystine Content in Nephropathic Cystinosis
The Journal of Pediatrics,

Dohil R et al. – Cystine crystal (CC) are easily visible in the intestinal mucosa. CC–GD counts appear to correlate with eGFR and may help monitor response to treatment. Even when mean white blood cells (WBC) cystine levels are low, the mucosal CC are not depleted suggesting that tissue cysteamine levels may not achieve therapeutic efficacy.

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