Cardiovascular risk in pediatric type 1 diabetes: sex-specific intima-media thickening verified by automatic contour identification and analyzing systems
Pediatric Diabetes,

Krebs A et al. – On the basis of sex differences of cardiovascular risk factors (cRFs) and carotid intima–media thickness (cIMT) in pediatric T1D, the assessment of sex–specific IMT percentiles facilitates a differentiated interpretation of subclinical atherosclerosis. The underlying diabetes and additional cRFs seem to be more important determinants of intima–media thickening than age. To improve the comparability of IMT measurements of relevant studies, the international harmonization of IMT measurements should be aimed for.

Methods
  • This cross-sectional analysis included clinical parameters, blood lipids, and B-mode ultrasound examination of the bilateral mean cIMT using an automatic contour identification procedure combined with computerized analysis.

Results
  • A total of 270 patients were eligible for evaluation (126 females, mean age 13.7 yr; 144 males, mean age 13.8 yr).
  • In the total group, cIMT was significantly related to sex and diabetes duration but not to age.
  • In males, cIMT was significantly higher than in females and sex-specific cIMT percentiles were calculated.
  • Both pulse pressure and diabetes duration in boys and low-density lipoprotein (LDL)-cholesterol, hemoglobin A1c (HbA1c), and diabetes duration in girls showed a significant association with cIMT.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Pediatrics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pediatrics Articles

1 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

2 Omalizumab in children Pediatric Drugs, November 25, 2014    Clinical Article

3 Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: Results from an Australian case-control study Cancer Causes and Control, October 31, 2014    Clinical Article

4 Case series of bifidobacterium longum bacteremia in three preterm infants on probiotic therapy Neonatology, November 10, 2014    Clinical Article

5 Long-term immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in 10- to 14-year-old girls: open 6-year follow-up of an initial observer-blinded, randomized trial The Pediatric Infectious Disease Journal, November 21, 2014    Clinical Article

6 Atenolol versus losartan in children and young adults with Marfan's syndrome New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

7 Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review American Journal of Clinical Nutrition, November 7, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis JAMA Pediatrics, November 12, 2014    Clinical Article

9 The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: A randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries Annals of Emergency Medicine, November 20, 2014    Clinical Article

10 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, September 11, 2014    Evidence Based Medicine    Review Article

11 Efficacy of a tetravalent dengue vaccine in children in Latin America New England Journal of Medicine, November 6, 2014    Evidence Based Medicine    Clinical Article

12 Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence International Archives of Allergy and Immunology, November 4, 2014    Clinical Article

13 Dysbiosis anticipating necrotizing enterocolitis in very premature infants Clinical Infectious Diseases, November 17, 2014    Clinical Article

14 Probiotics in the prevention of eczema: a randomised controlled trial Archives of Diseases in Childhood, October 22, 2014    Clinical Article

15 Outcome after anal intrasphincteric Botox injection in children with surgically treated Hirschsprung disease Journal of Pediatric Gastroenterology and Nutrition, November 3, 2014    Clinical Article

16 Fluticasone or montelukast in preschool wheeze: a randomized controlled trial Clinical Pediatrics, September 24, 2014    Clinical Article

17 Application of moisturizer to neonates prevents development of atopic dermatitis The Journal of Allergy and Clinical Immunology, October 14, 2014    Clinical Article

18 The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study International Journal of Obesity, November 14, 2014    Clinical Article

19 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, October 7, 2014    Evidence Based Medicine    Review Article

20 Association of early caffeine administration and neonatal outcomes in very preterm neonates JAMA Pediatrics, November 18, 2014    Clinical Article

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatricsmore