Effect of Rotavirus Vaccine on Reducing Acute Gastroenteritis in a Large Outpatient Pediatric Network
JAMA Pediatrics,

Nolan SM et al. – Rotavirus vaccine was associated with a significant reduction in outpatient AGE calls and episodes among immunized children in network in 2007. Despite a reduction in winter acute gastroenteritis (AGE) rates in the network, no difference was detected between RVV–immunized and rotavirus vaccine (RVV)–nonimmunized children for any outcome in 2008. Further study is needed to understand the lack of vaccine effect in 2008.

Methods
  • Practice-based network composed of 33 ambulatory pediatric practices in Philadelphia, Pennsylvania.
  • All children born from February 22, 2006 (date of RVV licensure), through February 29, 2008, and who received care at any network site.
  • The primary outcomes were AGE-related office visits, telephone calls, and episodes (composite outcome consisting of all visits and calls within a 10-day period).

Results
  • Rates of AGE visits in the 2 rotavirus seasons following the introduction of RVV steadily decreased from 3.0 AGE visits per 100 total office visits in the 2005 season to 1.8 in the 2008 season.
  • In 2007, vaccinations were administered to 9351 of 13 951 vaccine-eligible children (67.0%), and in 2008, they were administered to 9958 of 10 728 (92.8%).
  • Among RVV-immunized children in 2007, AGE calls and episodes were significantly reduced with vaccine effectiveness of 53% and 46%, respectively.
  • No significant difference was seen between RVV-immunized and RVV-nonimmunized children for any outcome in 2008.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pediatrics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pediatrics Articles

1 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

2 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, September 11, 2014    Evidence Based Medicine    Review Article

3 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, October 7, 2014    Evidence Based Medicine    Review Article

4 Application of moisturizer to neonates prevents development of atopic dermatitis The Journal of Allergy and Clinical Immunology, October 14, 2014    Clinical Article

5 Probiotics in the prevention of eczema: a randomised controlled trial Archives of Diseases in Childhood, October 22, 2014    Clinical Article

6 Fluticasone or montelukast in preschool wheeze: a randomized controlled trial Clinical Pediatrics, September 24, 2014    Clinical Article

7 Cow’s milk allergy: evidence-based diagnosis and management for the practitioner European Journal of Pediatrics, September 26, 2014    Review Article

8 Safety and effectiveness of continuous aerosolized albuterol in the non–intensive care setting Pediatrics, October 3, 2014    Clinical Article

9 Impact of removing iodized salt on the iodine nutrition of children living in areas with variable iodine content in drinking water European Journal of Nutrition, October 6, 2014    Clinical Article
Exclusive Author Commentary

10 Safety and effectiveness of continuous aerosolized albuterol in the non-intensive care setting Pediatrics, September 30, 2014    Clinical Article

11 Antiplaque and antigingivitis efficacy of triphala and chlorhexidine mouthrinse among schoolchildren - A cross-over, double-blind, randomized controlled trial Oral Health & Preventive Dentistry, October 23, 2014    Clinical Article

12 Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent US girls Pediatric Research, October 9, 2014    Clinical Article

13 Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted helminths are endemic Full Text PLoS Neglected Tropical Diseases, October 16, 2014    Free full text    Clinical Article

14 Randomized controlled trial of asthma risk with paracetamol use in infancy – a feasibility study Clinical & Experimental Allergy, October 13, 2014    Clinical Article

15 Trends in the age of diagnosis of childhood asthma The Journal of Allergy and Clinical Immunology, October 8, 2014    Clinical Article

16 Maternal perspectives on the use of probiotics in infants: a cross sectional survey Full Text BMC Complementary and Alternative Medicine, October 2, 2014    Free full text    Clinical Article

17 Race differences in the association between multivitamin exposure and wheezing in preterm infants Journal of Perinatology, October 10, 2014    Clinical Article

18 Effects of term infant formulas containing high sn-2 palmitate with and without oligofructose on stool composition, stool characteristics, and bifidogenicity Journal of Pediatric Gastroenterology and Nutrition, October 1, 2014    Clinical Article

19 Effect of preterm birth on exercise capacity: A systematic review and meta-analysis Pediatric Pulmonology, October 29, 2014    Evidence Based Medicine    Review Article

20 Overweight children report qualitatively distinct asthma symptoms: Analysis of validated symptom measures The Journal of Allergy and Clinical Immunology, October 28, 2014    Clinical Article

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatricsmore