Human Immunodeficiency Virus Disease Severity, Psychiatric Symptoms, and Functional Outcomes in Perinatally Infected Youth
JAMA Pediatrics,

Nachman S et al. – Human immunodeficiency virus illness severity markers are associated with the severity of some psychiatric symptoms and, notably, with cognitive, academic, and social functioning, all of which warrant additional study.

Methods
  • Cross-sectional analysis of entry data from an observational, prospective 2-year study.
  • Logistic and linear regression models adjusted for potential confounders were used.
  • Twenty-nine sites of the International Maternal Pediatrics Adolescent AIDS Clinical Trials Group study in the United States and Puerto Rico.
  • Youth aged 6 to 17 years who had HIV infection (N = 319).

Results
  • Characteristics of HIV were a current CD4 percentage of 25% or greater (74% of participants), HIV RNA levels of less than 400 copies/mL (59%), and current highly active antiretroviral therapy (81%).
  • Analyses indicated associations of past and current Centers for Disease Control and Prevention class C designation with less severe attention-deficit/hyperactivity disorder inattention symptoms, older age at nadir CD4 percentage and lower CD4 percentage at study entry with more severe conduct disorder symptoms, higher RNA viral load at study entry with more severe depression symptoms, and lower CD4 percentage at study entry with less severe symptoms of depression.
  • There was little evidence of an association between specific antiretroviral therapy and severity of psychiatric symptoms.
  • A lower nadir CD4 percentage was associated with lower quality of life, worse Wechsler Intelligence Scale for Children Coding Recall scores, and worse social functioning.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pediatrics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pediatrics Articles

1 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

2 Omalizumab in children Pediatric Drugs, November 25, 2014    Clinical Article

3 Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: Results from an Australian case-control study Cancer Causes and Control, October 31, 2014    Clinical Article

4 Case series of bifidobacterium longum bacteremia in three preterm infants on probiotic therapy Neonatology, November 10, 2014    Clinical Article

5 Long-term immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in 10- to 14-year-old girls: open 6-year follow-up of an initial observer-blinded, randomized trial The Pediatric Infectious Disease Journal, November 21, 2014    Clinical Article

6 Atenolol versus losartan in children and young adults with Marfan's syndrome New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

7 Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review American Journal of Clinical Nutrition, November 7, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis JAMA Pediatrics, November 12, 2014    Clinical Article

9 The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: A randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries Annals of Emergency Medicine, November 20, 2014    Clinical Article

10 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, September 11, 2014    Evidence Based Medicine    Review Article

11 Efficacy of a tetravalent dengue vaccine in children in Latin America New England Journal of Medicine, November 6, 2014    Evidence Based Medicine    Clinical Article

12 Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence International Archives of Allergy and Immunology, November 4, 2014    Clinical Article

13 Dysbiosis anticipating necrotizing enterocolitis in very premature infants Clinical Infectious Diseases, November 17, 2014    Clinical Article

14 Probiotics in the prevention of eczema: a randomised controlled trial Archives of Diseases in Childhood, October 22, 2014    Clinical Article

15 Outcome after anal intrasphincteric Botox injection in children with surgically treated Hirschsprung disease Journal of Pediatric Gastroenterology and Nutrition, November 3, 2014    Clinical Article

16 Fluticasone or montelukast in preschool wheeze: a randomized controlled trial Clinical Pediatrics, September 24, 2014    Clinical Article

17 Application of moisturizer to neonates prevents development of atopic dermatitis The Journal of Allergy and Clinical Immunology, October 14, 2014    Clinical Article

18 The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study International Journal of Obesity, November 14, 2014    Clinical Article

19 Rapid diagnostic tests for group a streptococcal pharyngitis: a meta-analysis Pediatrics, October 7, 2014    Evidence Based Medicine    Review Article

20 Association of early caffeine administration and neonatal outcomes in very preterm neonates JAMA Pediatrics, November 18, 2014    Clinical Article

Indexed Journals in Pediatrics: Pediatrics International, Journal of Pediatrics, Current Pediatricsmore