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Urinary incontinence in children: botulinum toxin is a safe and effective treatment option
Pediatric Surgery International, 01/18/2012
McDowell DM et al. – Botulinum neurotoxin type A (BoNT–A) has a role in a carefully selected subgroup of children with overactive bladder symptoms including those with medication side effects and treatment compliance issues. It may have a role in patients who do not respond to conventional therapy.
Methods- A 6-year retrospective study of children who received BoNT-A for OAB was performed.
- Treatment outcome was classified as complete success (CS), partial success (PS) or treatment failure (TF).
- Of the 57 patients who received BoNT-A treatment for OAB, 35 were males.
- CS occurred in 74.2% of males and 54.5% of females. PS was achieved in 20% of males and 18.2% of females.
- TF occurred in 2.9% of males and 22.7% of females.
- Anticholinergics had previously been used and had been effective in 58.6% and 83.3% of males and females.
- Significant side effects to medications were experienced in 12 (41.4%) males and 4 (22.2%) females.
- Of these, BoNT-A achieved CS in seven (53.3%) males and two (50%) females and PS in three (25%) males and one (25%) female.
- BoNT-A was successful in seven (58.3%) males and two (66.7%) females where anticholinergics were ineffective.
