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Role of GERD in Children with Otitis Media with Effusion
The Indian Journal of Pediatrics, 01/26/2012
Nair S et al. – Otitis media with effusion (OME) appears to be multifactorial disease.GERD may be one of the contributing factors in the etiopathogenisis of OME.
Methods- This is a prospective study conducted in a tertiary care hospital. Middle ear effusion samples were collected from 32 children undergoing surgery for OME.
- The samples were measured for pepsinogen level as well as total protein content.
- Samples were subjected to electrophoresis study by SDS PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis).
- A total of 21 patients out of 32 were found to have higher pepsinogen level in their middle ear effusion samples than the cut off value of 90 mg/ml.
- The lack of symptoms associated with GERD among the children in this study corroborates with other similar studies in the world literature.
- It was also statistically shown that the association between GERD score and pepsinogen level was insignificant (P?=?0.512).
