Obesity Susceptibility Loci on Body Mass Index and Weight Loss in Spanish Adolescents after a Lifestyle Intervention

The Journal of Pediatrics, 05/30/2012

Moleres A et al. – The genetic predisposition score (GPS) seems to have an important relationship with BMI–SDS and fat mass both at baseline and after a 3–month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.


  • Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes.


  • At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass.
  • After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements.
  • After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS.

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