Predictive Value of Serum Uric Acid Levels for the Diagnosis of Metabolic Syndrome in Adolescents
The Journal of Pediatrics, 05/18/2012
Wang JY et al. – In this longitudinal study, they found that serum uric acid (UA) is correlated with future WC, systolic blood pressure, triglyceride, and HDL–C and is a risk factor for developing MetS. UA might be valuable in predicting adolescent metabolic syndrome (MetS).
The authors enrolled male adolescents aged between 10 and 15 years at the baseline.
A total of 613 subjects were divided into quartiles according to their UA levels, from UA-1 (the lowest) to UA-4 (the highest).
After the mean follow-up period of 2.7 ± 0.97 years, 19 (3.1%) subjects developed MetS.
Waist circumference (WC), systolic blood pressure, high density lipoprotein cholesterol (HDL-C), and log triglyceride levels were significantly related to baseline UA levels.
Compared with the UA-1 group, subjects in the UA-4 group had significantly higher OR for abnormal WC, blood pressure, and HDL-C at the end of follow-up and had a 6.39-fold higher OR (95% CI 1.41-29.08; P < .05) for having MetS. Subjects with UA >7.6 mg/dL had a 4.32 (95% CI 1.57-11.93) higher risk of developing MetS.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.