Parenteral amino acid intakes: possible influences of higher intakes on growth and bone status in preterm infants

Journal of Perinatology, 05/03/2012

Scattolin S et al. – Early higher AA intakes improved growth without short–term AA intolerance. Nutritional parameters could influence bone growth. Lower limb length (LLL) was the anthropometric parameter that best correlated to bone status.


  • Newborns, weighing <1250g, received standard (S) or higher (H) parenteral AA intakes.
  • Anthropometry, biochemistry and quantitative ultrasound (metacarpus bone transmission time (mcBTT), in us) were measured prospectively.


  • A total of 55 patients in group S and 60 in group H were studied.
  • Significantly better growth rate was found in the H group during the study without signs of intolerance.
  • The authors found a significant decrease in mcBTT from birth to 21 days in the H group; nonetheless, mcBTT at 36 weeks of gestational age significantly positively correlated with early AA and energy intakes.
  • A significant positive correlation between mcBTT and lower limb length (LLL) at 21 days was found.

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