All glutathione forms are depleted in blood of obese and type 1 diabetic children

Pediatric Diabetes, 04/25/2012

Pastore A et al. – These findings consistently show in vivo evidence of glutathione depletion upon early onset of T1D and in obese children, thus evidencing glutathione as an early marker in these two metabolic conditions.


  • The authors assessed circulating levels of various glutathione forms by performing reverse-phase high performance liquid chromatography.
  • Glutathionyl-hemoglobin analysis was carried out by cation-exchange chromatography.


  • In children with T1D and in obese children, they found a significant decrease of all glutathione forms including, for the first time, the content of total glutathione and glutathionylated proteins.
  • The comparison among forms shows no significant imbalance in T1D patients, whereas in obese children it seems to suggest an attempt to rebalance the glutathione system homeostasis.

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