Factors Associated With Nonadherence to Thiopurines in Adolescent and Adult Patients With Inflammatory Bowel Disease
Journal of Pediatric Gastroenterology and Nutrition, 04/24/2012
Kamperidis N et al. – Adolescents are more frequently nonadherent than adults: prospective studies are required to determine the reasons for nonadherence in adolescents.
The authors sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels.
Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence interval [CI] 1.9–11.5]; P<0.01) compared with adults, patients with Crohn disease (OR 3.3 [CI 1.1–10.5] P=0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 [CI 1.0–1.1] P=0.02) were more likely to be nonadherent to thiopurines.
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